To determine a role of specific parameters of coagulation hemostasis for development of severe early-onset preeclampsia (еPE) in low-risk patients. Materials and Methods. A single-center prospective study included 40 patients with a physiological course of pregnancy and term delivery (control group) as well as 41 pregnant women with developed severe еPE (study group). Patients at the gestational age of 19–21 and 27–28 weeks in the comparison groups were examined for serum tissue factor (TF) activity, tissue factor pathway inhibitor (TFPI) and potential to generate thrombin in calibrated thrombography test. Results. Patients with developed ePE vs. control group were found to have significantly increased TF activity at both time points: 49.1 pmol/ml vs. 5.3 pmol/ml (p < 0.0001) and 56.7 pmol/ml vs. 6.6 pmol/ml (p < 0.0001), respectively. At gestational age of 19–21 weeks, patients in the study vs. control group had serum TFPI level significantly lower (1.1 U/ml vs. 1.6 U/ml; p < 0.0001) that was significant elevated up to 2.1 U/ml by 82 % at 27–28 weeks of pregnancy. At both time points, a significantly increased thrombin generation was detected in women with developed ePE. The development of ePE is characterized by increased potential to generate thrombin. TF has been identified as a more sensitive marker of activated coagulation hemostasis, and its significantly increased activity was recorded at gestational age of 19–21 weeks that allows us to consider TF as a prognostic biomarker.
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To study the factors leading to adverse perinatal outcomes allowing, on this basis, to predict degree of perinatal risk. Materials and Methods. The medical records of 155 patients who performed delivery in 2019–2021 were retrospectively analyzed. The following groups were formed: main group included 56 patients with adverse perinatal outcomes (9 fetuses died antenatally, 36 fetuses born below Apgar score 5, 9 newborns died within the first 168 hours of extrauterine life, 2 infant deaths). The control group included 99 patients with favorable perinatal outcomes. While assessing the data retrieved from medical records, sociobiological and laboratory-instrumental indicators, obstetric-gynecological and somatic anamnesis, the presence of extragenital pathology, the delivery process, information related to child condition at the time of birth and in early neonatal period were analyzed. In patients of the main group, significant differences were revealed compared to control group, respectively: high parity (3 or more deliveries) – 11 (19.6 %) and 15 (15.1 %) (p = 0.001); vomiting of pregnant women in early gestation – 27 (48.2 %) and 14 (14.1 %) (p = 0.005); the presence of uterine scar after two or more caesarean sections – 7 (12.5 %) and 2 (2.1 %) (p = 0.009); former abortions – 24 (42.8 %) and 16 (16.1 %) (p = 0.0017); acute respiratory viral infection in the first trimester – 21 (37.5 %) and 13 (13.1 %) (p = 0.005); threatened abortion in the second trimester – 23 (41.0 %) and 15 (15.1 %) (p = 0.0005); Doppler-based blood flow disorders in the second trimester – 17 (30.3 %) and 11 (11.1 %) (p = 0.008) and in the third trimester – 9 (16.0 %) and 3 (3.0 %) (p = 0.006); altered amniotic fluid index according to ultrasound data in the second trimester – 6 (10.7 %) and 1 (1.0 %) (p = 0.011); intrauterine growth retardation in the third trimester – 15 (26.7 %) and 4 (4.0 %) (p = 0.012); severe preeclampsia – 6 (10.7 %) and 1 (1.0 %) (p = 0.04). In patients of the main group, pregnancy was finished prematurely in 41.1 % of cases compared to 100% term delivery in control group. The risk factors identified, which were manifested in the first and second trimesters of pregnancy may be predictors for adverse perinatal outcomes. Based on the study results for patients of the main and control groups, it was convinced that the topic of predicting favorable and unfavorable perinatal outcome is currently far from being disclosed, which is a long meticulous path of search, analysis and comparison.
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In the article, the study of the stable movement of the working bodies on the working depth of the working bodies, which are movably attached to the frame and not equipped with a support device, in the soil tillage machines used in the agricultural production of our Republic, is the study of the stable movements of the working depth. the results of theoretical research on
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In recent years, the demand for better human health and harmless medicines has been increasing. Proper use of raw materials of medicinal plants is one of the goals before us. Aloe plant is a promising medicinal plant, products made from it have been used since ancient times and are still widely used in many fields of medicine. This article talks about the medicinal properties and importance of the aloe plant, which is widely used in folk medicine and rich in its composition.
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The article presents the fertility of irrigated meadow saz soils of Central Ferghana, where field experiments were carried out on growing the winter wheat variety "Davr" and the influence of sowing dates on its yield was determined. It has been established that when seeds are sown in early September, the yield and quality of winter wheat of the "Davr" variety reach a high level with the timely implementation of all agrotechnical processes in the conditions of irrigated meadow saz soils of Central Fergana.
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But in practice, cotton farmers have adopted the belief that "the more cultivation (cultivation, chiseling) is done between the rows of cotton, the better", so the deep softening of the rows continues even during the flowering period of cotton. Therefore, in our research in the following years, we studied the optimal number and duration of drawing cotton rows.
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Ecological education is a continuous psychological, moral and educational pedagogical tendency aimed at the formation of the environmental culture of the individual. At the same time, folk customs and traditions, as well as the environment for human upbringing, play an important role.
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The technological quality indicators of grain of varieties and lines studied in the experiment were determined in laboratory conditions with the necessary laboratory equipment, grain nature, transparency, gluten, IDK and group.
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The article presents the data obtained from the field experiments conducted in the conditions of typical gray soils prone to irrigation erosion of Tashkent region about the effect of soil tillage, seedling thickness and mineral fertilizer norms on its biometric indicators in the cultivation of winter wheat.
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This article discusses the psychology of employees of the internal affairs bodies and the psychological requirements for their professional activities. Stressful situations that arise in the professional activities of an internal affairs officer and ways to overcome them reveal the main psychological features of this area.
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SCIENCE & INNOVATION