α-lipoic acid is a very effective antioxidant for the treatment and prevention of diabetic neuropathy. The aim of this study was to evaluate the function of nitric oxide (NO) and stress proteins (HSP72) in insulin-dependent diabetes complicated by polyneuropathy and the contribution of these systems to the therapeutic effects of α-lipoic acid. In patients with diabetes, the amount of nitrite and nitrate in the blood plasma was almost 2 times lower than the norm. Treatment with α-lipoic acid completely normalized the plasma levels of these stable metabolites. Many patients also had low levels of hsp72. The positive clinical effect of a-lipoic acid was accompanied by the normalization of the synthesis of hsp72. Thus, the activation of no and HSP defense systems is involved in the therapeutic effect of a-lipoic acid in patients with diabetes mellitus (type 1 diabetes mellitus) with polyneuropathy is enough.
10.11.2022 Volume 1 Issue 7 View more Download
This article discusses issues related to the technologies for creating an information system based on a new information model and algorithms that help organize tourism processes. An algorithm for creating an information system for organizing and improving tourism processes and a development mechanism have been developed.
10.11.2022 Volume 1 Issue 7 View more Download
Phraseological units are considered one of the most interesting parts of the vocabulary. Analysis of translation and semantic features of phraseological units used in literature is one of the main issues of translation theory. This article aimed at investigating the translation and semantic features of phraseological units used in the Italian short stories. Theoretical data about phraseological units are discussed and analyzed with reasonable examples.
10.11.2022 Volume 1 Issue 7 View more Download
This article presents a number of novelties on the creation of a system architecture in the organization of tourism processes. In addition, system architecture information and software were discussed separately. The necessary information for tourists is provided when creating an information system for organizing and improving tourism processes.
10.11.2022 Volume 1 Issue 7 View more Download
Law is the foundation of a democratic state. Today, in our country, great initiative has been shown in the education of this field, and it is commendable that legal technical schools have been established. This article details the importance of legal education.
10.11.2022 Volume 1 Issue 7 View more Download
This article defines the role of a modern teacher in the era of high technology. It can be seen that today the foreign language teacher plays a decisive role in the organization of the educational process. Because it is the teacher who determines the goals, tasks, methods and organizational bases of teaching, and chooses appropriate textbooks and training manuals. For these reasons this article talks about the use of video materials in the improvement of visual and auditory skills of the advanced stage of language learning.
10.11.2022 Volume 1 Issue 7 View more Download
In practice, the article states that the teacher should be able to choose one of the linear or branched types of ATD or use them simultaneously, and with the linear type of ATD, students should be able to transfer all the volumes of educational information to them information about how they work and study in sequence order.
10.11.2022 Volume 1 Issue 7 View more Download
In this paper we will learn method of calculating integrals from using the Feynman method, which allows us to obtain an accurate analytical solution. Specific solutions of the examples are given. After reviewing the necessary theory, we will proceed to work through some examples and also in this article we will compute improper integral, definite integral and the Dirichlet integral in two technique.
10.11.2022 Volume 1 Issue 7 View more Download
The article considers STEM education as one of the tasks of renewed education in Uzbekistan, describes the conditions for increasing motivation for the subject "Astronomy" through the use of STEM technologies. Also in this article, methodological developments using STEM technology are presented, which can be used in astronomy lessons in high school.
10.11.2022 Volume 1 Issue 7 View more Download
SCIENCE & INNOVATION