Based on the results of a study of the acute toxicity of a mesh implant with a composite coating, the authors came to the conclusion that a mesh implant with a new composite coating can be classified as a low-toxic drug with a single injection. Based on the fact that a single injection of a mesh implant into the abdominal cavity didn`t cause death in animals, according to the currently accepted WHO classification, the toxicity of this composite coating can be classified as mild.
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The paper presents data on the study of the content of cytokines (IL-1β, RAIL-1β, IL-2, IL-4, IL-10, IL-17A, TNF-α, IFN-γ) in morning urine using enzyme immunoassay in healthy individuals (n=20) and in patients with acute glomerulonephritis (n=93). Determination of cytokine levels in patients was carried out at the onset of the disease and 12 months after the manifestation of the disease. The obtained indicators of cytokine content in urine are presented as absolute values in pg/ml and values normalized to creatinine, calculated using the formula: cytokine level (pg/ml) / urine creatinine (µmol/ml). A study was made of changes in the content of cytokines in urine during glomerulonephritis relative to a group of healthy individuals, as well as the dynamics of cytokine content in urine over a 12-month observation period. The results of the study showed that absolute values of cytokines in urine can distort the true picture of the cytokine profile of urine in kidney pathology. Normalized values of the predominant number of pro- and anti-inflammatory cytokines (IL-1β, IL-2, IL-8, IL-10, IL-17A and TNF-α) in patients with glomerulonephritis were significantly higher than the corresponding indicators in healthy individuals. Normalized cytokine values were shown to be more sensitive indicators than absolute values when analyzing differences in the cytokine profile in patients with glomerulonephritis depending on the acute and chronic course of the disease. These indicators influenced the outcome of glomerulonephritis, assessed, as a rule, 12 months after the manifestation of the disease. Thus, low levels of IL-1β, IL-8 and IL-17A found at the onset of the disease in combination with a high level of RAIL-1β determined the chronicity of glomerulonephritis. So, values of cytokine content in urine normalized by creatinine expand the possibilities of using assessment of the cytokine profile of urine to establish changes in the content of cytokines in urine in kidney pathology and predict the nature of the clinical course of glomerulonephritis.
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The article presents the results of experimental and morphological studies aimed at solving the issue of treating the cavity of an echinococcal cyst with various antiseptics and assessing the effectiveness of laser radiation. Experiments performed in the laboratory of Republican specialized scientific and practical medical center for surgery named after V.Vakhidov. The main objective of the experimental study was to evaluate the effect of laser exposure in combination with treatment with various antiseptics on the germinal elements of echinococcal fluid and the fibrous layer of the capsule of parasitic cysts. For this purpose, the study is divided into 2 large series. Each series was carried out sequentially. In the first series, the authors gave a macroscopic (visual) and microscopic assessment of each sample
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The article presents the results of experimental and morphological studies aimed at solving the issue of treating the cavity of an hydatid cyst with various antiseptics, and assessing the effectiveness of laser radiation. The main objective of the experimental study was to evaluate the effect of laser exposure in combination with treatment with various antiseptics on the germinal elements of echinococcal fluid and the fibrous layer of the capsule of parasitic cysts
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This article presents observations of ocular surface clinical condition in patients with primary open-angle glaucoma who had been receiving antihypertensive drugs containing preservatives over an extended period. The study comprises a total of 74 eyes, with patients categorized into three groups. The initial group consists of individuals who had been on a long-term regimen (up to 18 years) of antihypertensive medication containing benzalkonium as a preservative. The second group encompasses 12 patients (24 eyes) who were administered prostaglandin drugs via disposable dropper tubes, devoid of preservatives. The treatment duration for this group ranged from 2 to 2.5 years. Lastly, the third group comprised individuals exhibiting symptoms of conjunctivitis, chosen for the diagnosis of dry eye syndrome based on their subjective complaints. This group includes 10 patients, totaling 20 eyes. Upon analysis, approximately 40% of patients in the main group exhibited symptoms indicative of dry eyes. In the control group that received the preservative-free drug, the occurrence of dry eye symptoms was notably lower at 16.6%, while in the other control group, this frequency stood at approximately 30%. Consequently, the group consistently receiving drugs with a preservative showed a slightly higher percentage in the detection of dry eye
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This film study looks at the portrayal of environmental disaster in two different disaster films, namely "The Impossible" and "The Day After Tomorrow". Through a critical examination of narrative structures, visual symbolism and character dynamics, the paper explores the nuanced ways in which these films navigate the delicate balance between entertainment, education and ethical considerations. The analysis highlights the pros and cons of each film and considers their contributions to the broader discourse on environmental concerns and human resilience in the context of disaster cinema. The study also highlights the evolving landscape of cinematic representation and calls for a more responsible and nuanced approach to the portrayal of environmental disasters.
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The purpose of the article is to improve the quality and efficiency of education in the world, to pay special attention to the widespread use of pedagogical approaches in the processes of supporting students' education, rapid changes in the socio-economic sphere, to eliminate the problems of improving the education system, and at the same time to identify the possibilities of using innovative technologies in education. The issues of forming the necessary professional competencies on the basis of building an innovative model of technological processes for training future personnel and improving the content as a result of applying didactic, experimental, model, didactic, methodological, and socio-psychological approaches were discussed.
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Modern strategic changes in the socio-economic and political spheres of education, which have reduced the standard of living in our country, pose new challenges to the higher school teacher. They include concepts such as the need to master the structure of a new subject in education, ongoing changes and the acquisition of innovative technologies and methods of education that take into account the activity and independence of education recipients.
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SCIENCE & INNOVATION