RESEARCH OF ANTIOXIDANT AND PROOXIDANT PROPERTIES OF GLYCYRRHETIC ACID DERIVATIVES

I.Ya. Sattarova; I.N. Chuliev; M.I. Asrarov; B.A. Niyazmetov

doi:10.5281/zenodo.8116684

RESEARCH OF ANTIOXIDANT AND PROOXIDANT PROPERTIES OF GLYCYRRHETIC ACID DERIVATIVES

05.07.2023 International Scientific Journal "Science and Innovation". Series A. Volume 2 Issue 7

I.Ya. Sattarova, I.N. Chuliev, M.I. Asrarov, B.A. Niyazmetov

Abstract. It was studied the effect of new synthetic derivatives of glycyrrhetic acid (GRA) on the functional mitochondrial parameters, as well as the parameters of the CsA-sensitive pore of mitochondrial membranes in the article. For the first time it was shown that GRA derivatives 2-(N-cytisine)-ethyl-3-0-acetyl-18H-glycyrrhetate (cytisine-ethyl-HC), 2-(N-cytisine)-isopropyl-3-0-acetyl-18H-glycyrrhetate (cytisine-isopropyl-HC) and N-(2-pyridyl)-3-0-acetyl-11-ketoolean-12-en-30-amide (2-pyridyl-HC-amide) inhibited the activity of the CsA-sensitive pore and have a protective effect on mitochondrial membranes. At the same time, the damaging effect of Ca2+ ions and the LPO process decreases. Other GRA derivatives are N-(4-pyridyl)-3-0-acetyl-11-ketoolean-12-en-30-amide (4-pyridyl-HC-amide) and 2-(N-morpholine)-ethyl-3-0-acetyl-18βH-glycyrrhetate (morpholine-HC) uncouples OXPHOS, enhances the damaging effect of inducers of the CsA-sensitive pore on membranes, increasing their permeability to cations

Keywords: mitochondria, membrane permeability, CsA-sensitive pore, lipid peroxidation, oxidative phosphorylation (OXPHOS), antioxidants, prooxidants, free radicals, apoptosis, necrosis, glycyrrhetinic acid derivatives

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