INFLUENCE OF COMBINED SPINAL ANESTHESIA ON HEMODYNAMIC PARAMETERS AND STRESS MARKERS IN PRESCHOOL CHILDREN DURING UROLOGICAL SURGICAL INTERVENTIONS Abstract: Currently, in the practice of “adult” anesthesiologists, spinal anesthesia is a modern and effective method for urological surgical interventions. However, in pediatric anesthesiological practice, until recently, the use of SA was limited due to a number of objective and secondary reasons (anatomical and physiological beginnings of childhood; difficulty in verbal contact with young children; high risk of toxic effects of local anesthesiologists. In addition, spinal anesthesia in children), younger special age is associated with certain technical difficulties. In this connection, we conducted a comparative assessment of the state of central hemodynamics and autonomic status in preschool children during urological surgical interventions performed under combined spinal anesthesia in combination with intravenous sedation with propofol in a comparative aspect with combined general anesthesia based on sevoflurane and fentanyl.

RESEARCH ON THE ACUTE TOXICITY OF THE GRAIN OF INDIGOFERA TINCTORIA LINN Abstract: Some scientific sources provide information about the presence of toxic compounds for living organisms in the content of plants belonging to the Indigofera family. The aim of this research is to examine the overall impact and acute toxicity of the Indigofera tinctoria plant’s grain, belonging to the Fabaceae family, which were grown in the meadow-oasis soils in the “Abdurazzok-Mukhtarjon Yuksalish” farm, in the Uchkoprik district of the Fergana region. Experiments were performed on male non-purebred white laboratory mice with a body weight of 20±2.0 g. As a result of the research on the acute toxicity properties of the grain, it is determined that the grain of Indigofera tinctoria belongs to the class of non-toxic compounds.

TOTAL PROTEIN CONTENT IN THE PLANT INDIGOFERA TINCTORIA LINN Abstract: The article examines the study of the total protein content in the root, stem and grain of the plant Indigofera tinctoria L., a representative of the legume family (Fabaceae), grown in three different (fertile, saline, arid) climatic conditions of the Fergana region. The study used the Kjeldahl method, one of the generally accepted methods for determining the total protein content in the plant Indigofera tinctoria L. When determining the amount of protein in samples using the Kjeldahl method, the stages of hydrolysis with sulfuric acid, neutralization with sodium hydroxide and titration of the remaining acid with an alkali solution were carried out. The results obtained were compared with each other and with the amount of protein in other legumes. According to the results of the study, 25.967% protein was found in the grain of Indigofera tinctoria L. grown in arid conditions, 10.723% protein was found in the root under fertile conditions, and 5.688% protein was found in the stem under saline conditions.

KIDNEY AUTOTRANSPLANTATION IN PATIENTS WITH RENAL ARTERY PATHOLOGY Abstract: We have experience of 11 kidney autotransplantations in patients with various vascular pathologies (9 cases - renal artery stenosis caused by atherosclerosis, fibromuscular dysplasia and nonspecific Takayasu aortoarteriitis), 7 of which came back after previously performed stenting of the renal artery, 1 case - stenosis of the right renal artery with a poststenotic aneurysm). All patients suffered from renovascular hypertension. In all patients, the hypertension crisis exceeded the mark of 200/100 mmHg, with normal blood supply to the contralateral kidney. With long-term arterial hypertension, there is a high risk of developing hypertensive nephroangiosclerosis, with the level of systolic blood pressure (BP) playing a decisive role. Hypertensive nephroangiosclerosis often manifests itself later than damage to other target organs. Kidney pathology may remain unrecognized for a long time, however, with ineffective blood pressure control, manifestations of chronic heart failure increase and cardiovascular complications develop, often with fatal outcomes. Kidney autotransplantation with renal artery reconstruction has advantages when reconstructing the RA with an autovenous vein, in most cases there is an aneurysmal expansion of the autovenous vein. Kidney autotransplantation with renal artery reconstruction has advantages when using a synthetic linear prosthesis, due to neointimal hyperplasia at the anastomotic site, stenosis of the anastomotic orifice is possible. Reconstructions of the right renal artery are considered by technical difficulty due to the anatomical location of the aorta and inferior vena cava.

USING ESP TO RAISE STUDENTS' AWARENESS OF ENERGY AND SUSTAINABILITY ISSUES Abstract: The purpose of the study was to explore the idea of ESP teachers imparting basic knowledge and raising students' awareness of energy and sustainability issues in English classes at the university preparatory level. To achieve this goal, it was necessary to find out ESP teachers' thoughts about using ESP to teach sustainable development concurrently with English language teaching: their perceptions, opinions, beliefs, attitudes, knowledge and values. A language user must negotiate and debate environmental issues and be tactful to his/her interlocutor. Hence, learning a foreign language is important for the success of ESD. University students are language users in classes where they discuss sustainability and other issues using English as a foreign language. In general, the earth is in crisis and the oil and gas industry is a major producer of oil (which unknowingly contributes to CO2 emissions) with education as the key to solving related problems. Very recent studies have confirmed that university preparatory students lack knowledge about energy. There is a need for English language curriculum designers and higher education administrators involved in preparatory level education to consider using ESP to teach sustainability.

THEORETICAL ASPECTS OF PSYCHOLOGICAL AND PEDAGOGICAL DIAGNOSTIC METHODS IN PRACTICE Abstract: This problem can be solved only by students who have studied the discipline “Psychological and Pedagogical Diagnostics”. Psychological and pedagogical diagnostics, being one of the most important disciplines directly related to the practical activities of a vocational teacher, has recently received wide recognition. It acts as one of the ways to apply psychological knowledge in real life situations and occupies an important place in many areas of practical activity that need to take into account the psychological characteristics of a person. For effective assimilation of the presented material, activation of independent cognitive activity of students, development of their ability to link theory with practice, increasing interest and accessibility of the learning process, as well as for the purpose of developing the skills of psychological and pedagogical culture, the manual contains applications, including.

CONCEPT OF SOCIAL DANGER OF FRAUD AND DESCRIPTION Abstract: In this article, the author gives a general description of the concept of fraud and some of its specific aspects. In addition, the components of the structure of the fraud crime are analyzed, and the social danger of the fraud crime the concept was clarified. Also studied the opinions of scholars who conducted research on this topic and described the criminal-legal description of fraud.

THE EFFECTIVENESS OF MODERN TEACHING METHODS IN EDUCATION OF STUDENTS IN PRIMARY SCHOOLS Abstract: The study explores the importance of incorporating new teaching methods in primary schools to enhance the effectiveness and efficiency of the teaching and learning process. While traditional methods like the question-and-answer method, lecture, and demonstration still hold value, the rapid advancements in science and technology necessitate the adoption of modern teaching approaches. In modern education, the focus is on young learners’ active participation in class and their holistic development, moving away from the one-dimensional view of education where the teacher is the sole source of information transfer. The search for new ways and forms of organizing education has given rise to the concept of a "modern lesson" in the methodology of learning, contrasting with traditional lessons. The demands of pedagogy for lessons and the effectiveness of the pedagogical process are continually evolving. In addition to non-traditional lessons, schools are incorporating non-traditional teaching technologies alongside modern teaching methods. This article explores the utilization of modern teaching methods in educating primary school students.

FACTORS FOR IMPROVING PROFESSIONAL COMPETENCE OF INSPECTOR-PSYCHOLOGIST Abstract: This article discusses the research of the manifestation and development of competence factors in the activities of the inspector-psychologist and the improvement of his specific social-psychological factors, the determination of the social-psychological factors and components that develop the inspector-psychologist's social-psychological competence, the inspector-psychologist's communicative, research on the manifestation and development of emotional and personality components; in the development of the social-psychological competence of the inspector-psychologist, their connection with the social-legal system is revealed. Researching the psychological aspects of professional and social-psychological competence of employees in the world, research of socio-psychological factors of development of their professional competence, researches are being carried out to evaluate the professional competence of employees, to develop a set of special systematic psychological methods aimed at improving their professional competence, and to prevent crime. The impact of behavioral indicators on the professional activities of employees, their professional competence, in particular, improving the level of psychological preparation for professional activities by the Human Resources Professional Association (HRPA), particularly, to determine the socio-psychological factors and mechanisms of development of their professional competence, increasing the role of professional readiness of employees and determining the issue of their impact on the effectiveness of their activity is gaining urgent importance. In our republic increasing the efficiency of law enforcement agencies, special attention is being paid to the issues of further improvement of the system of training of inspector-psychologists on issues of minors and raising their level of professional training in recent years. Research on improving the professional competence of the inspector-psychologist on the issues of minors is of great importance in performing the important tasks specified in the legal documents. That's why, to increase the professional competence of inspector-psychologists on minor issues, to realize the characteristic features of their personal qualities, professional which directly affects the effectiveness of their professional activity through psychocorrective and developmental methods, formation of communicative and social-psychological competence factors is defined as an urgent problem.

FACTORS THAT DETERMINE THE MENTAL HEALTH OF FUTURE TEACHERS Abstract: This article examines the factors that influence and determine the mental health of future teachers. It is proved that the methodological and methodological foundations of research work have been developed.