INFLUENCE OF ORGANOCHLORINE COMPOUNDS ON SECRETORY ACTIVITY OF THE PANCREAS Abstract: In recent years new organochlorine pesticides have become widely used. Among them, hexochlorocyclohexane (HCH) is being introduced. This requires studying the toxic properties of the drug, as well as the development of hygienic standards for their composition in food products. The results of all experiments conducted with HCH allow us to conclude that it causes significant changes in the exocrine function of the pancreas, their direction and depth depend on the dose of the drug and the duration of its administration

STUDYING THE FACTOR MODEL OF PSYCHOPHYSIOLOGICAL AND SOMATOTYPIC STATUS OF YOUNG PEOPLE WITH THE AIM OF MODERATING THEIR PROFESSIONAL TRAINING Abstract: Somatotypic and psychophysiological parameters of the body are an important factor determining its health and the effectiveness of professional activities. Modeling and predicting personal characteristics based on data from mental physiological and somatotypic status will help young people choose a profession and increase the effectiveness of their professional activities.

THE ROLE OF THE PRESS IN COVERING THE CHANGES IN THE SOCIAL AND POLITICAL LIFE OF UZBEKISTAN DURING THE PERIOD OF RECONSTRUCTION Abstract: The article analyzes the role of the press in covering social and political problems and finding their solutions in the context of recent changes in Uzbekistan during the reconstruction process of 1985-1991. Based on the quantitative analysis, it was shown that the activity of the press is closely related to the events and events that are most relevant in the life of the society at the moment. It is based on the fact that the task of awakening the society through information media and eliminating accumulated complications was carried out with the help of the press.

PROVERBS AND THEIR GENERAL AND UNIVERSAL CHARACTER WERE STUDIED AND ANALYZED Abstract: The article examines the universal and national nature of proverbs, which are examples of folk art, and general similarities of proverbs belonging to different nations

MUSICAL NEEDS AND FACTORS OF THEIR POSITIVE ORIENTATION Abstract: Musical needs are formed in the listener under the influence of emotional and psychological influence, musical perception, musical preferences and social factors. According to their characteristics, they distinguish between physiological, intellectual-emotional and social needs. The need to listen to music is a spiritual and aesthetic need, and it is important to satisfy this need in students with high-quality works. According to A. Maslow's theory of needs, aesthetic needs are at one of the highest levels in the hierarchy of needs. The musical needs of any individual, individual or group are always different. In the process of perceiving musical works, through empathy, it is possible to awaken completely new needs, motives, activate, and involve a person in new psychological states and processes. If the need for musical activity is considered from the point of view of a person’s orientation, then it can be defined as a person’s mental state in the field of music, which creates the necessary conditions for the perception of a work. Musical needs and motives manifest themselves in a general or abstract-specific form and are always interconnected. Therefore, the systematic formation of students’ musical needs in educational activities has a positive impact on their deep understanding of the artistic content of the works they listen to.

RISK FACTORS FOR PNEUMONIA IN CHILDREN WITH CONGENITAL HEART DEFECTS Abstract: To identify risk factors for the development of pneumonia in children against the background of congenital heart defects. Materials and methods of research: 45 children aged from 1 year to 3 years were examined. Of these, 25 children with community-acquired pneumonia due to congenital heart disease (group I) and 20 children with community-acquired pneumonia without congenital heart disease (group II). To solve these problems, the following generally accepted and special clinical, functional and laboratory research methods were performed. Results: The research results showed that among the identified clinical variants of congenital heart defects, there were 14 (56%) children with VSD, 20% of children with ASD, 16% of children with combined defects and 8% of children with PDA. The study of medical and biological factors showed that in children of the 1st group girls predominated (60%), in the 2nd group boys were more common (75%). The mother's age was over 35 years at the time of the birth of this child, which prevailed in 1 group of children (24%) and in 16% of children the parents were close relatives. in children of group 1, in fact, among concomitant diseases, children with rickets prevailed in 80%, children with PPNS 48%, children with neurocirculatory dystonia 60%, and children with hip dysplasia in 24% of children

ADEQUATE TREATMENT OF ACNE IN ADOLESCENTS Abstract: The article presents current literature data on the mechanism of acne development. The results of our own observations of 48 patients who received adequate local therapy with the drug "Clintopic" gel and combined treatment with oral doxycycline monohydrate are shown and analyzed.

PHYSIOLOGICAL ASPECTS OF PAIN SENSITIVITY Abstract: The article describes the pathophysiological mechanisms of the formation and development of somatogenic and neurogenic pain syndromes. The pathophysiological and neurochemical aspects of hyperalgesia are considered. The results of immunohistochemical studies of the participation of excitatory amino acids, neuropeptides, nitric oxide, and Ca2+ ions in the mechanisms of sensitization are presented. The structural aspects of neurogenic pain syndromes are the formation in the central nervous system of aggregates of interacting sensitized neurons with impaired inhibitory mechanisms and increased excitability. Scientists associate the features of the pathogenesis of somatogenic and neurogenic pain syndromes with the principles of therapy for pathological pain

CREATINURIA Abstract: Creatinuria is the medical term for the presence of creatine in a patient's urine. Creatine is an important organic compound that plays a key role in energy metabolism in our body. Creatinuria can be the result of various factors, and its presence may indicate impaired renal function or other pathological conditions

FEATURES OF THE POSTOPERATIVE PERIOD IN CHILDREN WITH TETRALOGY OF FALLOT ACCORDING TO A RETROSPECTIVE ANALYSIS Abstract: The purpose of research: to study and identify anamnestic and characteristics of the postoperative period in young children with tetralogy of Fallot, by retrospective analysis. Materials and methods of research: in the aim of study incidence and structural postoperative complications in children with tetralogy of Fallot, we held a retrospective analysis of 52 case histories of young children with age of 1 to 10, acted on in the cardiac surgery department of the Tashkent Pediatric Medical Institute. Outcomes and discussions: The Analysis of results showed that the postoperative period in children with tetralogy of Fallot is characterized by the presence of different hemodynamic and infectious characters. the uprising which depending on the severity of the defect, the presence of concomitant diseases the volume of surgical intervention and the duration of Artificial Circulation