CRITERIA FOR THE EFFECTIVENESS OF RESEARCH AND PRODUCTION SPHERE Abstract: The article, based on scientific research of foreign experience and research work of domestic economists using the method of comparisons and mathematical calculations, substantiates the criteria that influence the formation of the scientific and production sphere and its efficiency

PROBLEMS OF IMPROVING THE FINANCIAL SYSTEM FOR SUPPORTING THE DEVELOPMENT OF SCIENCE AND TECHNOLOGY IN THE REPUBLIC OF UZBEKISTAN Abstract: The article analyzes investment projects and the possibilities for its improvement in the conditions of the national economy of Uzbekistan, and considers forms of investment in scientific research and development.

CLINICAL CHARACTERISTICS OF FORMATION OF HERBAL DEPOSIT IN CHILDREN Abstract: Recently, there has been an increase in the incidence of cholelithiasis in adolescents and children. Gallbladder disease in children is increasing in frequency (a rare disease) among diseases of the digestive system and has taken one of the leading positions. Gallstone disease is more common in school-aged children

EFFECT OF VIRAL HEPATITIS ON MENSTRUAL CYCLE DISORDERS IN ADOLESCENT GIRLS Abstract: This article provides a brief overview of the mechanisms by which viral hepatitis negatively affects the menstrual cycle of girls during prepubertal and pubertal periods of development. Hormonal imbalance, disruption of protein, fat and carbohydrate metabolism in hepatitis not only affects the development of reproductive function, but also negatively affects pregnancy, lactation and the formation and development of the fetus and newborn shown.

COMPARATIVE ANALYSIS OF PERINATAL OUTCOMES IN MECONIUM-STAINED AMNIOTIC FLUID Abstract: Several publications describe a strong correlation between fetal hypoxia and meconium-stained amniotic fluid, while others refute this link, focusing instead on the role of infection. Objective: To determine, based on dynamic cardiotocography, whether there is a connection between meconium-stained amniotic fluid and negative perinatal outcomes. Patients and methods: A prospective cohort study of perinatal outcomes was conducted on 27 parturients with antenatally detected hyperechogenicity in amniotic fluid based on transvaginal sonography. Conclusion. It is important to note that deliveries complicated by the presence of meconium in the amniotic fluid increase the risk of operative delivery via cesarean section for fetal indications, as they may lead to the development of newborn aspiration syndrome and increase the incidence of severe asphyxia at birth.

THE EFFECT OF IODINE DEFICIENCY ON REPRODUCTIVE FUNCTION IN GIRLS AND ADOLESCENT GIRLS IN CENTRAL ASIA Abstract: The main consequence of iodine deficiency in the environment is the development of goiter in people living in iodine-deficient regions (endemic goiter). In this regard, for a long time it was considered that goiter is the only manifestation of this condition. Currently, it has been proven that, in addition to goiter, iodine deficiency has other adverse effects on the health of girls. in the 20st century, the term ’endemic goiter" was replaced by the term "iodine deficiency diseases" (IDD). These diseases are caused by a decrease in the functional activity of the thyroid gland in response to iodine deficiency in the population of Central Asia.

WAYS TO CORRECT MENSTRUAL DYSFUNCTION IN WOMEN WITH OBESITY Abstract: According to the World Health Organization, the prevalence of obesity among women of reproductive age ranges from 1.8 to 25.3% in different countries [1]. Obesity has a negative impact on women's reproductive health. Disorders of the menstrual cycle in the context of obesity require special attention. This paper presents an analysis of methods for correcting menstrual dysfunction in obese women.

THE ROLE OF VIRAL AND MYCOPLASMA INFECTION IN THE GENESIS OF DEPLETED OVARY SYNDROME Abstract: The results of smear bacterioscopy evaluation showed that in women with hormonal disorders mycoplasma infection is detected in 5.7% of cases. In women with inflammatory processes, the detection rate of mycoplasma infection increases to 47.3%. In women with peritubar adhesions and purulent-septic complications, U.Urealiticum and M.hominis were detected in 78% of cases, gonorrhea in one, chlamydia in three, and trichomoniasis in five patients.

THE EFFECT OF INTESTINAL MICROBIOTA DISORDERS ON THE DEVELOPMENT OF PREMATURE BIRTH Abstract: Pregnancy is a complex and delicate process, the maternal body undergoes changes in hormones, immunity and metabolism during pregnancy to support fetal development. Microbes in the human body mainly live in the gut, and human gut microbiomes are complex and consist of more than 500-1500 different bacteria, archaea, fungi and viruses. Studies have shown that these microbes are not only involved in the digestion and absorption of food, but are also indispensable in regulating the health of the host. In recent years, there has been increasing evidence that microbiomes are important for pregnant women and the fetus. During pregnancy, there will be big changes in the gut microbiomes.

FORENSIC ASPECTS OF DIAGNOSING DIFFUSE AXONAL BRAIN DAMAGE IN TRAUMATIC BRAIN INJURIES Abstract: Diffuse axonal brain injury is a variant of severe traumatic brain injury, the main substrate of which is diffuse ruptures or tears of axons. Clinically, from the first minutes of injury, a coma with symptoms of brain stem damage is observed, which can turn into a vegetative state. Diagnosis is carried out based on traumatic history, clinical features and tomographic data. Treatment of coma consists of mechanical ventilation and intensive therapy; after recovery from coma, vascular, nootropic, metabolic drugs, physical therapy, psychostimulation, and speech therapy correction are used.