Primary microcephaly ( PMCF) is a neurodevelopmental disorder characterized by a small brain size, primarily due to a decrease in the cerebral cortex, and varying degrees of mental retardation (Woods et al., 2005;Mahmood et al., 2011;Phan and Holland, 2021;Zaqout and Kaindl, 2021;Gupta, 2023) and several additional neurological problems such as seizures and epilepsy (Shen et al., 2005), with a prevalence of 1/30,000 to 1/250,000. Brain development depends on neurogenesis, the process by which neural stem cells proliferate, migrate, and differentiate to form neurons, and is fundamental to normal brain development (Stiles and Jernigan, 2010;Исаев и др., 2019 ; Zhou et al., 2020 ). The formation of neurons begins during embryogenesis and continues throughout life. In mammals, the size of the cerebral cortex is determined by the number of neurons it contains (Borrell and Calegari, 2014). In general, an adult consists of about 86 billion neurons (Herculano-Housel, 2012), and the brain size varies from 975 to 1499cm3. Studies have shown that a decrease in the number of neurons leads to primary microcephaly, which is diagnosed when the circumference of the occipital-frontal region is less than two standard deviations below the average value at birth and/or less than three standard deviations below the average after 1 year of life. (Дуринкс и др., 2020 ).
03.02.2024 Volume 3 Issue 1 View more Download
The article presents the results of a scientific study on the non-traditional culture of Japanese medlar in Uzbekistan and the development of a new variety of this crop. Japanese medlar is an evergreen fruit and ornamental crop. In the conditions of the Tashkent region it can withstand frosts down to -18 0C. The fruits of the new variety “Yagona” are quite large, the average weight of one fruit is 36 grams. The maximum weight of the fetus is 55 grams. It produces a harvest every year; the yield of a 10-year-old tree averages 35 kg.
31.01.2024 Volume 3 Issue 1 View more Download
According to the World Health Organization, every year one in three of the world's population suffers from respiratory diseases, which make up 90% of all infectious diseases. The increasing incidence of the disease in the population, insufficient study of pathogenetic mechanisms and predictive factors, necessitates the need to carry out scientific research on this disease
31.01.2024 Volume 3 Issue 1 View more Download
In this article illustrated results of studying mechanical composition of 111 collection grape varieties from the RIPGR gene pool, where were analyzed valuable properties of grape varieties based on various directions. As a result of the researches have been identified suitable table and technical varieties of grape with higher economically valuable properties for growing in Tashkent region
31.01.2024 Volume 3 Issue 1 View more Download
The authors, as a result of the research work carried out, the frequency of general complications from 4 (9.7%) to 1 (2.2%) - an improvement of 7.5%, complications associated directly with EE - from 14 (34, 1%) to 3 (6.5%) and increase the number with no complications from 27 (65.9%) to 43 (93.5%), i.e. 1.4 times; improve excellent and good results from 9 (22.0%) to 37 (79.4%), i.e. 5.2 times; reduce the frequency of satisfactory results from 12 (29.3%) to 6 (13.0%) and poor results - from 11 (26.8%) to 2 (4.3%), which in general improved the results of surgical treatment of DE abdominal organs, i.e. achieve the research goal.
31.01.2024 Volume 3 Issue 1 View more Download
Relevance. The principles of postoperative multimodal analgesia are reflected in numerous publications; however, this issue remains insufficiently studied in pediatric cardiac surgery.
31.01.2024 Volume 3 Issue 1 View more Download
In this work, social and hygienic studies of the incidence of pneumonia and the reasons for the formation of a complicated course of pneumonia in young children were carried out. The most common syndromes aggravating the course of pneumonia were respiratory failure of varying degrees
31.01.2024 Volume 3 Issue 1 View more Download
This article discusses the causes of breast cancer, the leading cause of death among women in the world rankings, changes observed in women, symptoms, pathophysiology, stages, diagnosis and treatment, and treatment. The new approach included information on the use of apitherapy.
31.01.2024 Volume 3 Issue 1 View more Download
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