ENZYMATIC SYSTEM OF PROTECTION AGAINST OXIDATIVE STRESS

N. Hamzayeva; N. Yokubova

doi:10.5281/zenodo.6832490

N. Hamzayeva , N. Yokubova

Abstract. . Sirtuin genes are reported to act as sensors that detect the availability of cellular energy, leading to metabolic benefits, as calorie restriction prolongs life expectancy in organisms ranging from yeast to mammals. It has been shown that the mammalian orthologue Sir2, SIRT1 (sirtuin 1), activates a critical component of calorie restriction in mammals, that is, fat mobilization in white adipocytes. Recent studies suggest a key role of mammalian SIRT1 in an adequate cellular response to metabolic stress, such as nutrient deficiency or overload, and that SIRT1 and its activators play a role in protecting against the harmful effects of metabolic stressors.

Keywords: sirtuin, ROS productions, antioxidants, oxidative stress, metabolis.

References:

1. P, K. S. (2019). Cold Atmospheric Plasmas: Their Use In Biology And Medicine. Science 2. P.Sachdevae, T. A. (2013). The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease. Ageing Research Reviews, 867. 3. Pang, M. S.-G. (2019). Understanding the molecular mechanisms of bisphenol A action in spermatozoa. Clin Exp Reprod Med. 4. Patel SA1. (2014). Transcriptional control of antioxidant defense by the circadian clock. Antiox redox signaling, 20(18):2997-3006. 5. Paul S. Cooke, .. N. (2013). Safety Assessment including Current and Emerging Issues in Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology (Third Edition). 6. Paul⁎, M. D. (2019). Gallic acid protects rat liver mitochondria ex vivo from bisphenol A induced oxidative stress mediated damages. Toxicol Rep, 6: 578–589. 7. Roychoudhury*, K. D. (2014). Reactive oxygen species (ROS) and response of antioxidants as ROS-scavengers during environmental stress in plants. Front. Environ. Sci.