INFLUENCE OF COMBINED SPINAL ANESTHESIA ON HEMODYNAMIC PARAMETERS AND STRESS MARKERS IN PRESCHOOL CHILDREN DURING UROLOGICAL SURGICAL INTERVENTIONS

Satvaldieva E.A.; Shakarova M.U.; Mitryushkina V.A.

doi:10.5281/zenodo.12596587

INFLUENCE OF COMBINED SPINAL ANESTHESIA ON HEMODYNAMIC PARAMETERS AND STRESS MARKERS IN PRESCHOOL CHILDREN DURING UROLOGICAL SURGICAL INTERVENTIONS

30.06.2024 International Scientific Journal "Science and Innovation". Series D. Volume 3 Issue 6

Satvaldieva E.A., Shakarova M.U., Mitryushkina V.A.

Abstract. Currently, in the practice of “adult” anesthesiologists, spinal anesthesia is a modern and effective method for urological surgical interventions. However, in pediatric anesthesiological practice, until recently, the use of SA was limited due to a number of objective and secondary reasons (anatomical and physiological beginnings of childhood; difficulty in verbal contact with young children; high risk of toxic effects of local anesthesiologists. In addition, spinal anesthesia in children), younger special age is associated with certain technical difficulties. In this connection, we conducted a comparative assessment of the state of central hemodynamics and autonomic status in preschool children during urological surgical interventions performed under combined spinal anesthesia in combination with intravenous sedation with propofol in a comparative aspect with combined general anesthesia based on sevoflurane and fentanyl.

Keywords: spinal anesthesia, childhood, hemodynamic parameters, local anesthetics, urological surgical interventions.

References:

1. Devaykin. E.V., Svalov A.I. Central hemodynamics and autonomic nervous system functions during spinal anesthesia in younger children. Journal of Regional Anesthesia and Treatment of Acute Pain. 2010; 2 (4); 25–31 2. Shrestha R.M., Gurung S., Prajapati S.S., Pokharel В., Shrestha I. K. Hemodynamic changes after spinal anesthesia in children below the age of four years. Journal of Patan Academy of Health Sciences. 2021Aug;8(2):91-97. doi.org/10.3126/jpahs.v8i2.37690 3. Satvaldieva E.A., Shakarova M.U., Mamatkulov I.B., Use of Fast-track in pediatric urology. Journal of Urology 2022;4:52–55 Doi: https: //dx.doi.org/10.18565/urology.2022.4.52-55 4. Aleksandrovich Yu.S., Alimkhanova G.N., Pshenisnov K.V., Akimenko T.I., Bykov Yu.V., Razumov S.A. Indicators of stress response depending on the technique of anesthesia during the correction of anorectal anomalies in children. Journal of Regional Anesthesia and Treatment of Acute Pain. 2023;(2): 58‑64 doi: 10.17116/anaesthesiology202302158 5. Satvaldieva E.A., Shakarova M.U., Mitryushkina V.A.,Mamatkulov I.B., Poenov M.Y. Spinal anesthesia under ultrasonic control. Journal Science and innovation international scientific april 2024;3 (4): 204-209 6. Aleksandrovich Yu.S., Alimkhanova G.N., Pshenisnov K.V., Akimenko T.I., Razumov S.A. The effect of anesthesia on hemodynamic parameters during the correction of anorectal anomalies in children: a randomized trial. Bulletin of Intensive Care named after. A.I. Saltanova.2022 ;(4): 125‑134 doi.org/10.21320/1818-474X-2022-4-125-134 7. Koichi Yuki, Erika Matsunami Е., Kazumasa Tazawa, Wei Wang, James A. DiNardo, Koutsogiannaki S. Pediatric Perioperative Stress Responses and Anesthesia. Transl Perioper Pain Med. 2017; 2(1): 1–12. PMID: 28217718 8. Gupta A., Saha U. Spinal anesthesia in children: A review. J Anaesthesiol Clin Pharmacol. 2014 Jan-Mar; 30(1): 10–18.doi: 10.4103/0970-9185.125687 9. Dalens B. Spinal anesthesia update: what’s is new in pediatrics? Regional anesthesia and treatment of acute pain. 2011;5(2):10-13 10. Hermanns H., Stevens M.F., Werdehausen R., Braun S., Lipfert P., Jetzek-Zader M. Sedation during spinal anaesthesia in infants. Br. J. Anaesth.2006; 97: 308-304. 11. Anand K.J et.al. Repetitive neonatal pain and neurocognitive abilities in ex-preterm children. Pain. 2013; 154(10):1899-1901. 12. Walker S.M., Yaksh T.L. Neuraxial analgesia in neonates and infants: A review of clinical and preclinical strategies for the development of safety and efficacy data Anesth. Analg. 2012; 115:638-662. 13. Williams R.K., Adams D.C., Aladjem E.V., Kreutz J.M., Sartorelli K.H., Vane D.W. et al. The safety and efficacy of spinal anesthesia for surgery in infants: The Vermont Infant Spinal Registry. Anesth. Analg. 2006;102: 67-71 14. Finkel J.C, M.Goil Boltz, A.M.Conran. Haemodynamic changes during high spinal anaesthesia in children having open heart surgery. Pediatric Anesthesia 2003; 13(1):48-52 15. Tkachenko S.V., Chadaev Yu.M. Features of spinal anesthesia in children. Paediatric surgery 2016; 3-4 (52-53): 90-95 16. Ozer Y., Ozer T., Altunkaya H., Savranlar A. The posterior lumbar dural depth: an ultrasonographic study in children. Agri. 2005; 17: 53–57. 17. Tirmizi H. Spinal anesthesia in infants: recent developments. Curr. Opin Anaesthesiol. 2015; 28(3): 333-338 18. Khmyzov A.A. Spinal anesthesia in children. Medicine of emergency conditions 2016; 2 (73): 64-73 19. Paton R. H. Spinal anaesthesia in older children in the United Kingdom: personal experience. Anaesthesia. 2008; 63: 1149–1150 20. Ecoffey C., Lacroix F., Giaufre E., Orliaguer G., Courreges P. Association des Anesthesistes Reanimateurs Pediatriques d’Expression Française (ADARPEF) Epidemilogy and morbidity of regional anesthesia in children: A follow-up one-year prospective survey of the FrenchLanguage Society of Pediatric Anesthesiologists (ADARPEF). Paediatr. Anaesth. 2010;20: 1061-1069. 21. Satvaldieva E.A., Shakarova M.U., Mamatkulov I.B. Spinal anesthesia in children: possibilities and rational approach. Journal of Pediatrics.Toshkent 2021;2: 356 –362 22. Eschertzhuber S., Hohlrieder M., Keller C., Oswald E., Kuehbacher G., Innerhofer P. Comparison of high - and low-dose intrathecal morphine for spinal fusion in children. Br. J. Anaesth. 2008; 100: 538-543 23. Apiliogullari S., Duman A., Gok F., Ogun C. O., Akillioglu I. The effects of 45 degree head up tilt on the lumbar puncture success rate in children undergoing spinal anesthesia. Paediatr. Anaesth. 2008; 18: 1178–1182 24. Eschertzhuber S., Hohlrieder M., Keller C., Oswald E., Kuehbacher G., Innerhofer P. Comparison of high - and low-dose intrathecal morphine for spinal fusion in children. Br. J. Anaesth. 2008; 100: 538-543 25. Kachko L., Simhi E., Tzeitlin E., Efrat R. et al. Spinal anesthesia in neonates and infants: a single-center experience of 505 cases. Pediatr. Anesth. 2007; 17: 647–653 26. Imbelloni L. E., Vieira E. M., Sperni F., Guizellini R. H., Tolentino A. P. Spinal anesthesia in children with isobaric local anesthetics: report on 307 patients under 13 years of age. Paediatr. Anaesth. 2006; 16: 43–48 27. Lee J.H., Chung K.H., Lee J.Y. et al. Comparison of fentanyl and sufentanil added to 0.5% hyperbaric bupivacaine for spinal anaesthesia in patients undergoing cesarean section. Korean Jurnal of Anaesthesiology. 2011; 60(2):103-108 28. Parthasarathy S, T Senthilkumar. Age-based local anesthetic dosing in pediatric spinal anesthesia: Evaluation of a new formula – A pilot study in Indian patients. Anesthesia essays and researches 2017 (11): 627-629 29. Sing B.L., Siddiqui F.J., Leong W.L. et al. Hyperbaric versus isobaric bupivacaine for spinal anaesthesia for caesarean section. Cochrane Database Syst. Rev. 2016;15(9)