25.06.2024 International Scientific Journal "Science and Innovation". Series D. Volume 3 Issue 6
Abstract. Relevance. Transplantation is the only radical treatment for end-stage liver disease. Improving the results of liver transplantation directly depends on the preparation of recipients, careful selection of donors, surgical technique and methods of rehabilitation in the postoperative period. Despite the positive results achieved in the survival of recipients after transplantation, the complication rate is still high, which requires further research in this direction. The purpose of the study: to analyze the results of the initial stage of the introduction of related liver transplantation in the Republic of Uzbekistan. Research materials. For the period from February 12, 2018 to February 2024, 96 related transplantations of the right lobe of the liver were performed in patients with decompensated liver failure of various etiologies. Research results. The postoperative period in recipients passed without complications in 55 cases, which amounted to 57.3%, in the remaining 41 patients (42.7%), one or more complications were noted after the intervention. Thus, among 41 patients, the development of 72 different complications (from 1 to 3 complications) was noted. At the same time, complications that occurred in 21 patients (21.9%) in the early postoperative period required relaparotomy. Among 41 patients, 15 patients (15.7%) died in the early postoperative period, in the long-term period (3 years after transplantation) there was another 1 death in a patient with chronic rejection against the background of refusal to take immunosuppressive drugs. In general, among the recipients operated at the center for the period from 2018 to 2024, the nearest satisfactory results were obtained in 84.4%, while in the long-term period this figure was 79.2% Summary. The analysis showed that the survival rates of grafts and recipients to a large extent depend on the characteristics of surgical tactics, nosology, and the severity of the initial state of the recipient. At the initial stages of the implementation of the program, the so-called “center effect” is essential.
Keywords: liver transplantation, end-stage liver disease, complication rate, living related donors.
SCIENCE & INNOVATION