ASSESSMENT OF THE QUALITY OF LIFE ON THE MSIS-29 SCALE IN PATIENTS WITH MULTIPLE SCLEROSIS
01.06.2024
International Scientific Journal "Science and Innovation". Series D. Volume 3 Issue 5
Madjidova Y.N., Ochilova D.F.
Abstract. The article provides data on the results of the study of the diagnosis of multiple sclerosis. Multiple Sclerosis Impact Scale 29 (MSIS-29) is a proven and reliable scale for assessing the quality of life of patients with multiple sclerosis. .
In the last decade, some progress has been made in studying the pathogenesis and developing methods for treating demyelinating diseases. PC is classified as a multifactorial disease. For its occurrence, a combination of hereditary predisposition and external influences (for example, viral infection) is necessary. Among the mechanisms of implementation of these pathogenic factors, autoimmune reactions and chronic inflammatory process are of leading importance.
The causes of occurrence, features of clinical manifestations and prognosis of these disorders have been studied extremely rarely. Improving diagnostic methods and the presence of erased forms of MS dictate the need to study the characteristics of the MS clinic and conduct a more thorough differential diagnosis with other demyelinating diseases.
Keywords: multiple sclerosis, MSIS-29, cognitive sphere, the physical aspect, psychological component, affective disorders.
References:
1. E. I. Gusev, T. L. Demina. Multiple sclerosis. Department of Neurology and Neurosurgery (Head - Academician of the Russian Academy of Medical Sciences, Prof. E. I. Gusev) RSMU, Moscow
2. Srirm S. et l. Chlmydipneumonie infection of the centrl nervous system in multiple sclerosis (англ.) // nnls of neurology. — 1999. — Vol. 46, no. 1. — P. 6—14. Архивировано 7 ноября 2016 года.
3. Gusev E.I., Demina T.L. Multiple sclerosis // Consilium Medicum: 2000. - № 2.
4. Blakemore WF, Smith KJ. Node-like axonal specializations along demyelinated central nerve fibres: ultrastructural observations. ActaNeuropathol. 1983;60(3-4):291–296.
5. Celesia GG, Daly RF. Visual electroencephalographic computer analysis (VECA). A new electrophysiologic test for the diagnosis of optic nerve lesions. Neurology. 1977 Jul;27(7):637–641.
6. Ghatak NR, Hirano A, Lijtmaer H, Zimmerman HM. Asymptomatic demyelinated plaque in the spinal cord. Arch Neurol. 1974 Jun;30(6):484–486.
7. Imaizumi T, Lankford KL, Waxman SG, Greer CA, Kocsis JD. Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord. J Neurosci. 1998 Aug 15;18(16):6176–6185.
8. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444–1452.
9. Jeffery ND, Blakemore WF. Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination. Brain. 1997 Jan;120(Pt 1):27–37.
10. Ascherio A. Epidemiology of multiple sclerosis: from risk factors to prevention / A. Ascherio, K. Munger // Semin. Neurol. – 2008. – Vol. 28, N 1. – P. 7–28.
11. Cerebral and spinal MRI examination in patients with clinically isolated syndrome and definite multiple sclerosis / M. Sailer, F. Fazekas, A. Gass [et al.] // Rofo. – 2008. – Vol. 180, N 11. – P. 994–1001.
12. Chabas D. Recent advances in the immunology of multiple sclerosis / Chabas // Rev. Neurol. – 2006. – Vol. 162, N 2. – P. 162–173.
13. Шмидт Т. Е. Ведение больных с рассеянным склерозом / Т. Е. Шмидт, Т. Д. Жученко // Рос. мед. журнал. – 2004. – № 3. – C. 46–48.
14. Рассеянный склероз с поздним дебютом / Э. З. Якупов, Т. В. Матвеева, Хакимова, И. Ф. Хафизова // Невролог. вестник. Журн. им. В.М. Бехтерева. – 2010. – №. 1. – С. 66–70.