Abstract. Whooping cough is an acute infectious bacterial disease, the main symptom of which is a paroxysmal cough, characterized by a rather severe clinical course, as well as often the development of serious complications from the respiratory and nervous systems in children of different ages. The article presents the results of an analysis of the incidence of whooping cough and the quality of vaccine prevention according to seromonitoring data of 111 children, of which 76 children with health problems aged from 3 to 10 years, 34 boys (44.74%) and 42 girls (55.26%). ) vaccinated against whooping cough, on an individual schedule, in a family clinic. The control group consisted of 35 relatively healthy children. The work assessed the immunological activity in children with health problems vaccinated against whooping cough. Determination of class G (IgG) antibody titers using enzyme-linked immunosorbent assay (ELISA). Sera with IgG antibody levels above 11 units were considered seropositive. The results of the study showed that in the 76 children we examined with health problems, 2/3 were patients with frequent acute respiratory viral infections 48(63.16±1.21%) (P<0.05). When vaccinating against whooping cough in children with health problems and a high incidence of previous diseases, the level of anti-whooping cough antibodies was 27.63% of children. Recommendations are presented that an inadequate immune response to vaccination against whooping cough in children with health problems allows us to consider such children as a group at increased risk for ineffective vaccination and justifies the need to use individual tactics when immunizing them.
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