FORENSIC TOXICOMETRY AND TANATOGENESIS IN ACUTE COMBINED POISONINGS

Yakubov Khayot Khamidullaevich; Kadirov Kuralbay Urazbayevich; Otakulov Sohibjon Ismatillaevich

doi:10.5281/zenodo.11098445

Yakubov Khayot Khamidullaevich, Kadirov Kuralbay Urazbayevich, Otakulov Sohibjon Ismatillaevich

Abstract. The nosology of acute poisoning is extremely diverse and differs significantly in different countries. In Uzbekistan, the bulk of poisoning is accounted for by alcohol and its surrogates, acids (mainly acetic) and alkalis, various medications, mainly hypnotics and sedatives, organophosphorus and other pesticides. The biological activity of chemical compounds is determined by their structure, physical and chemical properties, dose (concentration) and duration of exposure; features of intake and biotransformation in the body; resistance of tissues and organs to poisons and the individual characteristics of a particular victim. In this regard, the forensic medical assessment of concomitant acute poisoning is a very relevant and unresolved problem.

Keywords: toxicokinetics, toxicodynamics, resistance of tissues and organs, structural portrait, specific and nonspecific effects of poisons, toxicometry, toxicometric parameters, mean lethal concentration, probit analysis

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