DEVELOPMENT OF A NEW DOMESTIC BIOCOMPATIBLE COMPOSITE MESH IMPLANT AND EVALUATION OF ITS EFFECTIVENESS IN VENTRAL HERNIA SURGERY IN AN EXPERIMENT

Sadikov Rustam Abrarovich; Babadjanov Azam Khasanovich; Nosirov Muzaffar Madaminovich

doi:10.5281/zenodo.11032003

DEVELOPMENT OF A NEW DOMESTIC BIOCOMPATIBLE COMPOSITE MESH IMPLANT AND EVALUATION OF ITS EFFECTIVENESS IN VENTRAL HERNIA SURGERY IN AN EXPERIMENT

22.04.2024 International Scientific Journal "Science and Innovation". Series D. Volume 3 Issue 4

Sadikov Rustam Abrarovich, Babadjanov Azam Khasanovich, Nosirov Muzaffar Madaminovich

Abstract. The scientific article presents the results of the development of a new domestic biocompatible composite mesh implant and an assessment of its effectiveness in ventral hernia surgery in an experiment.Experimental studies were conducted in 109 laboratory rats in the Department of Experimental Surgery of the Russian Academy of Medical Sciences named after Academician V.Vakhidov. In laboratory rats, the formation of a postoperative ventral hernia was performed, followed by non-tensioning hernia repair using a polypropylene mesh in the Onlay position and a similar mesh with a composite coating. At various times (7.14, 21 and 30 days), the engraftment of the mesh implant and the features of tissue healing were studied. Experimental studies have shown that during Onlay alloplasty, a pronounced inflammatory reaction develops in the surrounding tissues within 7-10 days and there was a partial divergence of the peritoneum in the area of mesh fixation. A morphological assessment of the features of the engraftment of a mesh prosthesis with a composite coating with a photosensitizing property under the action of laser irradiation showed that it causes a less pronounced inflammatory reaction, while the coating also provided an increase in the degree of adhesion of the prosthesis to tissues and, accordingly, the strength of restoring the integrity of the anterior abdominal wall.

Keywords: experimental postoperative ventral hernia, Onlay allogernioplasty, mesh prosthesis, domestic biocompatible composite coating, photosensitization, laser irradiation

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