SCIENCE & INNOVATION

METHOD FOR CORRECTING METABOLIC AND IMMUNOPATOLOGICAL DISORDERS IN CHILDREN WITH EXOGENOUS CONSTITUTIONAL OBESITY

13.03.2024 International Scientific Journal "Science and Innovation". Series D. Volume 3 Issue 3

Guzaliya Khasanova

Abstract. The results of our own study of weight correction, metabolic and immunopathological disorders in overweight and obese adolescent children are presented. Aim: Development of a treatment and preventive program for weight correction, metabolic and immunopathological disorders in overweight and obese children. Materials and methods: 60 adolescents were examined: 40 with exogenous constitutional obesity of the first degree, 20 with overweight. Studies were carried out on the levels of adiponectin, highly sensitive C-reactive protein, lipid spectrum in the blood plasma, as well as bacteriological examination of feces. The developed treatment and preventive program was applied to 50 children, divided into 4 groups: the main ones - 20 obese children (1) and 10 overweight children (2), who received a course of probiotic medication as part of the developed treatment and preventive program. The control groups included 20 obese children (3) and 10 overweight children (4), who, for a number of reasons (parental abandonment, child abandonment, financial situation in the family), did not receive a probiotic drug as part of the weight correction program. The results were assessed after 6 and 12 months, with repeated paraclinical studies. Results: Assessment of the level of CRP-hs after 12 months of application of the developed treatment and prophylactic program demonstrated a decrease in the activity of CRP-hs and an increase in the level of adiponectin (from 4.06 ± 0.06 to 2.4 ± 0.03 and from 5.0 ± 0 .13 to 12.23±0.08 mg/ml, respectively), a significant (p <0.05) decrease in total cholesterol levels (from 6.09±1.07 to 4.85±0.93 mmol/l) and triglycerides (from 2.05±0.17 to 1.12±0.29 mmol/l), as well as normalization of the quantitative and qualitative composition of the intestinal microbiota, the degree of dysbiotic disorders and the disappearance of signs of bacterial contamination in the main groups of children, compared with the control in groups. Stabilization of body weight, disappearance of signs of metabolic and immunopathological disorders after 12 months of use of the developed treatment and preventive program in the complex treatment of obesity allow us to recommend its use in both group and individual treatment.

Keywords: obesity, children, metabolic and immunopathological disorders, correction