Abstract. A new viral infection, called "COVID-19" in the spring of 2020, took on a pandemic character. Data on the impact of Covid-19 on a pregnant woman and fetus are few and contradictory. The aim of the study was to study the clinical and laboratory features of coronavirus infection in pregnant women. An analysis was made of 222 birth histories of women with laboratory-confirmed PCR for COVID-19, sent for delivery to a specialized obstetric department in October-December 2020. The results of our studies showed that 70.2% had a mild form of infection, 21.2% had a moderate form, and 8.1% had a severe form. The frequency and nature of lesions of the upper and lower respiratory tract, SPO2 parameters and lung lesions, as well as the age of pregnant women, parity, and the presence of somatic pathology are presented. Conclusions. In most pregnant women, a severe form of COVID-19 is characterized by bilateral pneumonia with ARS against the background of anemia in 100% of cases. Severe COVID-19 infection was more common in pregnant women aged 35 years and older. The condition of pregnant women with COVID-19 aggravated the development of severe preeclampsia, premature detachment of the placenta, and multiple pregnancies.
References:
1. Временный национальный стандарт РУз по ведению больных с COVID-19. Восьмая версия.21.09.2020. Ташкент.
2. Джумаев К.Ч., Ешимбетова Г.З., Дроненко Л.М.Течение беременности, родов и послеродового периода у женщин с подтвержденным COVID-19.// Международная научно-практическая конференция. «Здоровье женщины – здоровье нации» Самарканд, 21 января 2021. Биология ва тиббиёт муаммолари 2021, №1.1 (126) 83-85.
3. Львов Д.К., Альховский С.В., Колобухина Л.В., Бурцева Е.И. Этиология эпидемической вспышки COVID-19 в г.Ухань (провинция Хубэй, Китайская Народная Республика), ассоциированной с вирусом 2019-CoV (Nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, подрод Sarbecovirus): уроки эпидемии SARS-CoV . //Вопросы вирусологии. 2020; 65(1): 6-15.DOI: https://doi.org/10.36233/0507-4088-2020-65-1–6-15
4. Организация оказания медицинской помощи беременным, роженицам, родильницам и новорожденным при новой корона-вирусной инфекции COVID-19. Методические рекомендации. Версия 1 (24.04.2020). Министерство здравоохранения Российской Федерации, 2020. 61 с. Режим доступа:https://static-1rosminzdrav.ru/system/attachments /attaches/000/050 /093/original/23042020_Preg_COVID-19_1_Final.pdf. [Дата доступа: 30.04.2020].
5. Романов Б. К. Коронавирусная инфекция COVID-2019.// Безопасность и риск фармакотерапии. 2020; 8(1): 3–8. https://doi.org/10.30895/2312-7821-2020-8-1-3-8.
6. Юпатов Е.Ю., Мальцева Л.И., Замалеева Р.С., Зефирова Т.П., Чечулина О.В., Мазитова М.И., Курманбаев Т. Новая коронавирусная инфекция COVID-19 в практике акушера-гинеколога: обзор современных данных и рекомендаций// Акушерство, Гинекология и Репродукция 148 http://www.gynecology.su Научный обзор Review article 2020 • Том 14 • № 2.C 147-158.
7. Abbasi-Oshaghi E., Mirzaei F., Farahani F., Khodadadi I., Tayebinia H. Diagnosis and Treatment of Coronavirus Disease 2019 (COVID-19): Laboratory, PCR, and Chest CT Imaging Findings // International Journal of Surgery. 2020. URL: https://doi.org/10.1016/j. ijsu.2020.05.018 (дата обращения: 15.05.2020).
8. Chen H., Guo J., Wang C. et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.Lancet.2020;395(10226):P809–15. DOI: 10.1016/ S0140-6736(20)30360-3
9. Coronavirus (COVID-19) infection in pregnancy. Royal College of Obstetricians and Gynaecologists: London, 2020. 61 p. Available at: https://www.rcog.org.uk/globalassets/documents/guidelines/2020-04-17-coronavirus-covid-19-infection-in-pregnancy.pdf. [Accessed: 30.04.2020]
10. Guidance for management of pregnant women in COVID-19 pandemic.
11. ICMR–National Institute for Research in Reproductive Health, 2020.17p. Available at: http://www.nirrh.res.in/wp-content/uploads/2020/04/ Guidance-for-Management-of-Pregnant-Women-in-COVID-19-Pandemic.pdf. [Accessed: 30.04.2020]
12. Lippi G., Plebani M. Laboratory Abnormalities in Patients with COVID-2019 Infection // Clin Chem Lab Med. 2020. URL: https://doi. org/10.1515/cclm-2020-0198 (дата обращения: 17.05.2020).
13. Liu W., Wang Q., Zhang Q. et al. Coronavirus disease 2019 (COVID-19) during pregnancy: A case series. Virology Articles. Preprints 2020; 2020020373. Available at: https://www.preprints.org/manuscript/ 202002.0373/v1. [Accessed: 30.04.2020].
14. Lou J., Tian S.-J., Niu S.-M. et al. Coronavirus disease 2019: a
15. bibliometric analysis and review. Eur Rev Med Pharmacol Sci. 2020; 24 (6): 3411–21. DOI: 10.26355/eurrev_202003_20712.
16. Report of the WHO-China joint mission on Coronavirus disease-2019
17. (COVID-19). World Health Organization. 16-24 February 2020. 40 p.
18. Available at: https://www.who.int/docs/default-source/coronaviruse/
19. who-china-joint-mission-on-covid-19-final-report.pdf. [Accessed: 30.04.2020]].
20. Royal College of Obstetricians and Gynaecologists: London, 2020. 61 p. Available at: https://www.rcog.org.uk/globalassets/documents/guidelines/2020-04-17-coronavirus-covid-19-infection-in-pregnancy.pdf. [Accessed: 30.04.2020]].
21. Zhai P., Ding Y., Wu X., Long J., Zhong Y., Li Y. The Epidemiology, Diagnosis and Treatment of COVID-19 // International Journal of Antimicrobial Agents. 2020. URL: https://doi.org/10.1016/j.ijantimicag.2020.105955 (дата обращения: 16.05.2020)
22. Zheng F., Tang W., Li H. et al. Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha. Eur Rev Med Pharmacol Sci.2020;24(6):3404–10. DOI: 10.26355/eurrev_202003_20711.
SCIENCE & INNOVATION