Abstract. This study was conducted in experiment fields in the Plant Science department of Tashkent State Agrarian University in 2014-2016. The experiment was performed in split-plot design with 4 replications. Based technology for the use of biostimulator Microzym-2 under peanut cultivation, determined the economic efficiency of the studied peanut varieties depending on the agro technological elements in obtaining a high and quality yield. When using the biostimulator Microzym-2 with a rate of 30 l/t before sowing peanut seeds, the yield of pods of the "Salomat" variety was higher by 0,14 t/ha, and the "Mumtoz" variety by 0,11 t/ha compared to the control (0,12 t/ha). When using mineral fertilizers with a rate of N150P150K100 kg/ha with the introduction of the biostimulator Microzym-2 before sowing seeds, as well as in the phase of flowering-pods formation, the grain yield of the Salomat variety was 2,93 t/ha, and that of the Mumtoz variety was 3,32 t/ha.