RELAXANT EFFECT OF VINCAMINE HYDROCHLORIDE AND PYROZALIN IODIDE ALKALOIDS ON AORTIC SMOOTH MUSCLE CELLS VIA CA2+ L-CHANNELS

Allaniyazova Zuxra Durisbergen qizi; Adilbekov Takhir Tukhtaevich; Usmanov Pulat  Bekmuradovich; Yuldashev Nasirdjan Mukhamedjanovich

doi:10.5281/zenodo.10251461

Allaniyazova Zuxra Durisbergen qizi, Adilbekov Takhir Tukhtaevich, Usmanov Pulat Bekmuradovich, Yuldashev Nasirdjan Mukhamedjanovich

Abstract. In this study, the results of the effects of vincamine hydrochloride and pyrozalin iodide alkaloids on the relaxation of aortic smooth muscle cells in the presence of Ca2+ L-channels have been reported. The isometric contraction activity of the aortic blood vessel smooth muscle derived from rabbits was studied using mechanography. The results, under in vitro conditions, demonstrated that the contraction activity of the rabbit aortic blood vessel smooth muscle preparation induced by 50 mM KCl was dependent on the potential of the plasma membrane, associated with the activity of the Ca2+L-channels. It was found that vincamine and pyrozalin iodide alkaloids had an effect on the blockage of the Ca2+L-channels and a reduction in [Ca2+] concentration. The obtained results suggest that the relaxing effect of vincamine hydrochloride and pyrozalin iodide alkaloids is based on the blockage of the L-type Ca2+ channels, and they also affect the receptor-operated Ca2+ channels. In conclusion, the results indicate that in providing the relaxing effect of vincamine and pyrozalin iodide alkaloids, the blockage of potential-dependent L-type Ca2+ channels, along with the blockage of receptor-operated Ca2+ channels, plays an important role.

Keywords: Smooth muscle cell, aorta, ion channels, vasorelaxant

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