INDICATORS OF IMPAIRED PERMEABILITY AND INFLAMMATION IN THE INTESTINE IN CHILDREN WITH AUTISM SPECTRUM DISORDER OF THE REPUBLIC OF  UZBEKISTAN

Mirdjuraeva N.R.; Nurmatova Sh.O.; Safarova S.A.

doi:10.5281/zenodo.10211045

INDICATORS OF IMPAIRED PERMEABILITY AND INFLAMMATION IN THE INTESTINE IN CHILDREN WITH AUTISM SPECTRUM DISORDER OF THE REPUBLIC OF UZBEKISTAN

27.11.2023 International Scientific Journal "Science and Innovation". Series D. Volume 2 Issue 11

Mirdjuraeva N.R., Nurmatova Sh.O., Safarova S.A.

Abstract. The association of dysbacteriosis with diseases of the central nervous system has been proven in the last 10 years [1]. Microbial changes cause an increase in intestinal permeability, and the penetration of bacterial fragments and toxins induces local and systemic inflammatory processes affecting distant organs, including the brain [3,4,6]. Thus, the integrity of the intestinal epithelial barrier plays a central role in the microbiota-gut-brain axis. In this review, we discuss recent evidence for faecal calprotectin, an important regulator of intestinal epithelial cell tight contacts, which is thought to play a key role in maintaining blood-brain barrier function [3,4,10].

Keywords: autism spectrum disorder, microbiota, calprotectin, zonulin, rehabilitation

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