THE ROLE OF FOLATE METABOLISM GENES POLYMORPHISMS IN INTELLECTUAL DISORDER IN CHILDREN WITH CEREBRAL PALSY

Nurmatova Shoira Oktyabrevna; Omonova Umida Tulkinovna; Rahimova Kamola  Esanboevna

doi:10.5281/zenodo.10211017

THE ROLE OF FOLATE METABOLISM GENES POLYMORPHISMS IN INTELLECTUAL DISORDER IN CHILDREN WITH CEREBRAL PALSY

27.11.2023 International Scientific Journal "Science and Innovation". Series D. Volume 2 Issue 11

Nurmatova Shoira Oktyabrevna, Omonova Umida Tulkinovna, Rahimova Kamola Esanboevna

Abstract. We studied polymorphisms of C677T in the MTHFR gene, A1298C in the MTHFR gene, A276G in the MTR gene, II22Met in the MTRR gene and their influence on the psychological development of cerebral palsy. Based on this, we examined 97 children aged 1 to 14 years who suffered from various forms of cerebral palsy and were at risk of developing cerebral palsy. The gender ratio is 3:2, 59 boys and 38 girls. V.K. Registered in Republican Children's Psychoneurological Hospital named after Kurbanova. for 2020-2022. The control group consisted of 90 healthy children. The diagnosis is made on the basis of anamnesis, neurological condition, results of instrumental and genetic studies

Keywords: cerebral palsy, risk factors, clinical presentation, diagnosis, children, folate cycle gene polymorphism, GMFCS, MTHFR, MTRR, MTR, developmental delays, mental retardation, specific development of school skills.

References:

1. Федеральные клинические рекомендации по оказанию медицинской помощи детям с детским церебральным параличом. М.: СПР. 2013:28 с. 2. Aboutorabi A., Arazpour M., AhmadiBani M., Saeedi H., Head J.S. Efficacy of ankle foot orthoses types on walking in children with cerebral palsy: a systematic review. Ann. Phys. Rehabil. Med. 2017; 60(6): 393-402. 3. Andrew MJ, Parr JR, Montague-Johnson C, et al. Optimising nutrition to improve growth and reduce neurodisabilities in neonates at risk of neurological impairment, and children with suspected or confirmed cerebral palsy.BMCPediatr 2015; 15:22. 4. Blair E. A systematic review of risk factors for cerebral palsy in children born at term in developed countries. Dev. Med. Child Neurol. 2013; vol. 55(6): 499-508. 5. Chen M., Li T., Lin S., Bi D., Zhu D., Shang Q., Ma C., Wang H., Wang L., Zhang Y., He L., Zhu C., Xing Q. Association of Interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: a case-control study. Cytokine. 2013; vol. 61(3): 826-30. 6. Das J., Lilleker J., Shereef H., Ealing J. Missense mutation in the ITPR1 gene presenting with ataxic cerebral palsy: description of an affected family and literature review. Neurol. Neurochir. Pol. 2017; vol. 51(6): 497-500. 7. Ellenberg J.H., Nelson K.B. The association of cerebral palsy with birth asphyxia: a definitional quagmire. Dev. Med. Child Neurol. 2013; vol. 55(3): 210-6. 8. Ganesan V. Outcome and rehabilitation after childhood stroke. Handb.Clin. Neurol. 2013; vol. 112: 1079-83. 9. Gibson C.S., Maclennan A.H., Dekker G.A., Goldwater P.N., Sullivan T.R., Munroe D.J., Tsang S., Stewart C., Nelson K. Candidate genes and cerebral palsy: a population-based study. Pediatrics. 2008; vol.122(5): 1079-85. 10. Resch B., Müller W.D. Interleukin-6-174 CC polymorphism is associated with clinical chorioamnionitis and cerebral palsy. Ann. Neurol. 2010; vol. 68(5): 768-9. 11. Juraevna, G. D. (2022). Psychological views on the role of parents in raising children in the family. ACADEMICIA: An International Multidisciplinary Research Journal, 12(10), 143-147. 12. Juraevna, D. G. (2022). Preparing young boys and girls for family life. Web of Scientist: International Scientific Research Journal, 3(6), 1513-1517. 13. Juraevna, G. D. (2021). Prevention of divorce by preparing young people for family life. ACADEMICIA: An International Multidisciplinary Research Journal, 11(12), 398-401. 14. GAFFOROVA, D. (2023). Provoking factors of family breakdown in modern society. Transnational Journal of Medicine & Health, 2(10), 3-5. 15. GAFFOROVA, D. (2023). Psychoprophylaxis of monthly conflict generating disagreements in modern society. Young Scholar’s Academic Journal, 2(7), 5-7. 16. Schaefer G.B. Genetics considerations in cerebral palsy. Semin.Pediatr. Neurol. 2008; vol. 15(1): 21-6. 17. Schiariti V., Fowler E., Brandenburg J.E., Levey E., Mcintyre S., Sukal-Moulton T., Ramey S.L., Rose J., Sienko S., Stashinko E., Vogtle L., Feldman R.S., Koenig J.I. A common data language for clinical research studies: the National Institute of Neurological Disorders and Stroke and American Academy for Cerebral Palsy and Developmental Medicine Cerebral Palsy Common Data Elements Version 1.0 recommendations. Dev. Med. ChildNeurol. 2018; vol. 60(10): 976-986