MORPHOLOGICAL CHANGES IN ELEMENTS OF THE KNEE JOINT UNDER THE INFLUENCE OF EXPERIMENTAL HYPOTHYROSIS
12.11.2023
International Scientific Journal "Science and Innovation". Series D. Volume 2 Issue 11
Eshonkulova B.D, Mirsharapov U.M, Ibrakhimov Sh.F.
Abstract. A decrease in the activity of the thyroid gland, or rather the presence of thyroid harmonization in a low blood concentration, leads to the fact that the metabolism in the body gets out of control, as a result of which pathological changes develop to some extent. Its hypofunction occurs due to several factors: iron injuries, tumor and cystic diseases, neurosalts of the pituitary-hypothalamic system, defects in iron development, surgical errors, long-term use of thyreostatics, etc. The situation with hypothyroidism is one of the most common among the population, iodine deficiency is among the regional ones for our country.
This article describes the morphological and morphometric changes in the elements of the knee joint in early ontogenesis in the generation of mothers caused by experimental hypothyroidism during pregnancy. The model of experimental hypothyroidism and the results of the study allow early detection of morphofunctional changes in the elements of the knee joint in generations born from this disease
Keywords: experimental; subchondral; thyrotropin; metaphysis; chondrocyte; hypothyroidism; triiodothyronine; thyroxine; synovial; knee joint: morphological; musculoskeletal; tendon; deformity
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