ANTIMICROBIAL ACTIVITIES OF EXTRACTS OF PLANTS BELONGING TO ASTERACEAE FAMILY ENDEMIC FOR  UZBEKISTAN

Kh.Kh. Dolimov; S.M.Xaydarov

doi:10.5281/zenodo.10058804

ANTIMICROBIAL ACTIVITIES OF EXTRACTS OF PLANTS BELONGING TO ASTERACEAE FAMILY ENDEMIC FOR UZBEKISTAN

31.10.2023 International Scientific Journal "Science and Innovation". Series D. Volume 2 Issue 10

Kh.Kh. Dolimov, S.M.Xaydarov

Abstract. The increase in the number of diseases that threaten human health in the world causes the need to create new pharmacological drugs to expand year by year. In this regard, the use of natural compounds of plants and their synthetic analogues in the field of pharmaceuticals opens up wide opportunities. In this study the antimicrobial activities of the extracts obtained from 16 endemic plants belonging to the Asteraceae against Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli) and yeast (Candida albicans) were studied. According to obtained results, ethyl alcoholic extracts were more active compered low polar solvents extracts. Moreover, Achillea filipendulina, Cynara scolymus, Artemisia leucodes, Artemisia annua, Erigeron canadensis, Handelia trichophylla, Lactuca sp., Onopordum acanthium and Tragopogon malicus extracts showed different levels of activity.

Keywords: antimicrobial, extracts, antibiotics, endemic plats

References:

1. Deshmukh Gao, Y.H.; Zheng, R.; Li, J.; Kong, W.S.; Liu, X.; Ye, L.; Mi, Q.L.; Kong, W.S.; Zhou, M.; Yang, G.Y.; et al. Three new diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii. J. Asian Nat. Prod. Res. 2019, 21, 316322. 2. Habboush Y, Guzman N. Antibiotic Resistance. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023 Jan. 3. Aslam B, Khurshid M, Arshad MI, Muzammil S, Rasool M, Yasmeen N, Shah T, Chaudhry TH, Rasool MH, Shahid A, Xueshan X, Baloch Z. Antibiotic Resistance: One Health One World Outlook. Front Cell Infect Microbiol. 2021 Nov 25;11:771510. doi: 10.3389/fcimb.2021.771510. 4. Nowbuth AA, Asombang AW, Tazinkeng NN, Makinde OY, Sheets LR. Antimicrobial resistance from a One Health perspective in Zambia: a systematic review. Antimicrob Resist Infect Control. 2023 Mar 3;12(1):15. doi: 10.1186/s13756- 023-01224-0. PMID: 36869351; PMCID: PMC9982795. 5. Kot B. Antibiotic Resistance Among Uropathogenic Escherichia coli. Pol J Microbiol. 2019 Dec;68(4):403-415. doi: 10.33073/pjm-2019-048. 6. Yakovlev, S.A. Infectious diseases as a global problem of our time/ S.A. Yakovlev // Territory of Science. 2017. S. 98-113 7. Qi, X., Wang, E, Xing, M., Zhao, W., and Chen, X. (2012). Rhizosphere and non- rhizosphere bacterial community composition of the wild medicinal plant Rumex patientia. World J. Microbiol. Biotechnol. 28, 22572265. doi:10.1007/s11274-012- 1033-2. 8. Barba-Ostria C, Carrera-Pacheco SE, Gonzalez-Pastor R, Heredia-Moya J, Mayorga-Ramos A, Rodríguez-Pólit C, Zúñiga-Miranda J, Arias-Almeida B, Guamán LP.Evaluation of Biological Activity of Natural Compounds: Current Trends and Methods. Molecules. 2022 Jul 13;27(14):4490. doi: 10.3390/molecules27144490. 9. Vaou N, Stavropoulou E, Voidarou C, Tsigalou C, Bezirtzoglou E. Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives. Microorganisms. 2021 Sep 27;9(10):2041. doi: 10.3390/microorganisms9102041. 10. Chassagne F, Samarakoon T, Porras G, Lyles JT, Dettweiler M, Marquez L, Salam AM, Shabih S, Farrokhi DR and Quave CL (2021) A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective. Front. Pharmacol. 11:586548. doi: 10.3389/fphar.2020.586548 11. Bakhora Turaeva, Azam Soliev, Farkhod Eshboev, Lukhmon Kamolov, Nodira Azimova, Husniddin Karimov,Nigora Zukhritdinova and Khurshida Khamidova. The use of three fungal strains in producing of Indole-3-acetic acid and Gibberelllic acid.Plant Cell Biotechnology and Molecular Biology 21(35&36):32-43; 2020 12. Salmerón-Manzano E, Garrido-Cardenas JA, Manzano-Agugliaro F. Worldwide Research Trends on Medicinal Plants. Int J Environ Res Public Health. 2020 May 12;17(10):3376. doi: 10.3390/ijerph17103376. 13. Antibacterial, antifungal and cytotoxic activities of eight Asteraceae and two Rubiaceae plants from Columbian biodiversity: Jaim N, Diana M Narvaez, Oscar M.Mosquera. 2007 14. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Disk Susceptibility Tests. CLSI document M02. 13th Edition. PA, USA. (2018). 15. Askarova, O.K., Bobakulov, K.M., Muradov, M.T. et al. Constituent Composition and Antimicrobial Activity of Essential Oil from Scutellaria oxystegia. Chem Nat Compd 58, 355357 (2022). https://doi.org/10.1007/s10600-022-03679 16. Aldughaylibi FS, Raza MA, Naeem S, Rafi H, Alam MW, Souayeh B, Farhan M, Aamir M, Zaidi N, Mir TA. Extraction of Bioactive Compounds for Antioxidant, Antimicrobial, and Antidiabetic Applications. Molecules. 2022 Sep 13;27(18):5935. doi: 10.3390/molecules27185935 17. Sasidharan S, Chen Y, Saravanan D, Sundram KM, Yoga Latha L. Extraction, isolation and characterization of bioactive compounds from plants' extracts. Afr J Tradit Complement Altern Med. 2011;8(1):1-10. Epub 2010 Oct 2. 18. Palanichamy, P.; Krishnamoorthy, G.; Kannan, S.; Marudhamuthu, M. Bioactive potential of secondary metabolites derived from medicinal plant endophytes. Egypt. J. Basic Appl. Sci. 2018, 7, 303312. https://doi.org/10.1016/j.ejbas.2018.07.002. 19. Rana, K.L.; Kour, D.; Sheikh, I.; Dhiman, A.; Yadav, N.; Yadav, A.N.; Saxena, A.K. Endophytic Fungi: Biodiversity, Ecological Significance, and Potential Industrial Applications. In Recent Advancement in White Biotechnology Through Fungi; Springer Nature Switzerland AG: Cham, Switzerland, 2019; pp. 162. https://doi.org/10.1007/978-3-030-10480-1_1. 20. Teixeira, T.R.; Santos, G.S.D.; Armstrong, L.; Colepicolo, P.; Debonsi, H.M. Antitumor Potential of Seaweed Derived-Endophytic Fungi. Antibiotics 2019, 8, 205. https://doi.org/10.3390/antibiotics8040205. 21. Caruso, D.J.; Palombo, E.A.; Moulton, S.E.; Zaferanloo, B. Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds. Microorganisms 2022, 8, 1990. https://doi.org/10.3390/microorganisms10101990. 22. Wen, J.; Okyere, S.K.; Wang, S.; Wang, J.; Xie, L.; Ran, Y.; Hu, Y. Endophytic Fungi: An Effective Alternative Source of Plant-Derived Bioactive Compounds for Pharmacological Studies. J. Fungi 2022, 20, 205. https://doi.org/10.3390/jof8020205. 23. Abolghasem, G.B.; Abdollah, G.P.; Hamidreza, J.; Ali, S.; Ahmadreza, G. Chemical compositions, yield and antioxidant activity of the essential oil of hyssop (Hyssopus officinalis L.) under intercropping with fenugreek (Trigonella foenum‐graecum L.). Nat. Prod. Res. 2023, 37, 675–680. 24. Sharifi-Rad, J.; Quispe, C.; Kumar, M.; Akram, M.; Amin, M.; Iqbal, M.; Koirala, N.; Sytar, O.; Kregiel, D.; Nicola, S.; et al. Hyssopus Essential Oil: An Update of Its Phytochemistry, Biological Activities, and Safety Profile. Oxid. Med. Cell Longev. 2022, 13, 8442734. https://doi.org/10.1155/2022/8442734. 25. Venditti, A. Essential oil composition, polar compounds, glandular trichomes and biological activity of Hyssopus officinalis subsp. Aristatus (Godr.) Nyman from central Italy. Ind. Crops Prod. 2015, 77, 353363. https://doi.org/10.1016/j.indcrop.2015.09.002. 26. Pirbalouti, A.G. Chemical compositions and antioxidant activity of essential oils from inflorescences of two landraces of hyssop Hyssopus officinalis L. subsp. angustifolius Bieb. cultivated in southwestern, Iran. J. Essent. Oil Bear. Plants 2019, 22, 10741081. https://doi.org/10.1080/0972060X.2019.1641431. 27. Rusanova, M.; Rusanov, K.; Butterweck, V.; Atanassov, I. Exploring the capacity of endophytic fungi isolated from medicinal plants for fermentation and phenolics biotransformation of rose oil distillation wastewater. Biotechnol. Biotechnol. Equip. 2019, 33, 651663. https://doi.org/10.1080/13102818. 28. Mallouk, S.; Mohamed, N.S.; Debbab, A. Cytotoxic Hydroperoxycochliodinol Derivative from Endophytic Chaetomium sp. Iso- lated from Salvia officinalis. Chem. Nat. Compd. 2020, 56, 701705. https://doi.org/10.1007/s10600-020-03123