28.10.2023 International Scientific Journal "Science and Innovation". Series D. Volume 2 Issue 10
Abstract. This article examined the influence of pomegranate bark extract on the thyroid hormone levels and thyrotropic activity of the pituitary gland in rats that were fed a low-iodine diet and exposed to external radiation on the 25th day of their life. It was demonstrated that pomegranate bark extract led to an increase in the concentration of thyroid hormones in rats with normal growth, normalization of thyroid hormone levels in iodine-deficient rats, in rats exposed to radiation during the adolescent growth period, and in rats subjected to both of these factors. Additionally, a correlation with the duration of extract application was observed. Furthermore, regardless of the duration of pomegranate bark extract usage, there was a pronounced stimulation of thyrotropic pituitary activity in all groups of rats under investigation. These findings suggest that pomegranate bark extract holds promise as a potential preventive measure for thyroid function disorders, pending further experimental research into its mechanism of action, dose determination, and duration of application
Keywords: pomegranate bark extract, thyroid hormones, iodine deficiency, thyrotropic activity.
SCIENCE & INNOVATION