METABOLIC CHANGES IN THE BODY AS THE RESULT OF LONG-TERM USE OF ARTIFICIAL SWEETENER-SODIUM CYCLAMATE

Khabibullaev Sanjarbek Murodilla ugli; Yuldashev Nasirdjan Mukhamedjanovich; Mamazulunov Nurmukhammad Khusanboy ugli

doi:10.5281/zenodo.10003469

METABOLIC CHANGES IN THE BODY AS THE RESULT OF LONG-TERM USE OF ARTIFICIAL SWEETENER-SODIUM CYCLAMATE

14.10.2023 International Scientific Journal "Science and Innovation". Series D. Volume 2 Issue 10

Khabibullaev Sanjarbek Murodilla ugli, Yuldashev Nasirdjan Mukhamedjanovich, Mamazulunov Nurmukhammad Khusanboy ugli

Abstract. The study aims to evaluate the effect of sodium cyclamate, a sweet flavoring substance, on carbohydrate metabolism in rats after long-term administration. Sodium cyclamate was administered orally at a dose of 10 mg/kg daily to rats for 60 days. To study biochemical indicators in the blood of animals, blood was taken from animals before cyclamate injection (control group), on the 30th and 60th days of the experiment. On the 60th day, the animals were slaughtered and the amount of glucose and glycogen in their liver was studied. It was found that long-term consumption of sodium cyclamate leads to significant disturbances of metabolic processes in the body. Significant hyperglycemia and hyperinsulinemia developed from the 30th day. Long-term administration of cyclamate developed insulin resistance in animals. Administration of cyclamate also led to strong changes in blood biochemical indicators. The obtained results make it possible to limit the use of sodium cyclamate in the food industry or to propose replacing it with another natural sugar substitute.

Keywords: sodium cyclamate, insulin resistance, hyperglycemia, glycated hemoglobin, blood biochemical indicators

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