THE MECHANISM OF GLUCOSE TRANSPORTERS THROUGH THE MEMBRANE

Yuldosheva Sevinch Bakhtiyor qizi; Namozova Bibixonim Uvayevna; Yusupova  Raykhona Khairullahevna; Ismailova Gulzira Orinbaevna

doi:10.5281/zenodo.7881223

Yuldosheva Sevinch Bakhtiyor qizi, Namozova Bibixonim Uvayevna, Yusupova Raykhona Khairullahevna, Ismailova Gulzira Orinbaevna

Abstract. This article discusses the mechanisms of membrane transport of glucose transporters. Glucose can be taken up and metabolized in cells. For most mammals, glucose is readily imported by the membrane transporter diff Glut (SLC2A) family facilitators. A person has 14 Glut equipment. For at least half of them, the main physiological substrate is unclear or unknown. Glucose transporter isoforms are Gluts 1-4, which regulate glucose homeostasis and have kinetic planning

Keywords: glucose transporters, insulin, beta cells, easy diffusion, physiological substrate, glucose homeostasis, kinetic planning

References:

1. Mitani T, Hoshikawa H, Mori T, Hosokawa T, Tsukamoto I, Yamaguchi F, et al. Growth inhibition of head and neck carcinomas by D-allose. Head Neck. 2009; 31:1049–1055. doi: 10.1002/hed.21070. 2. Palazzo M, Gariboldi S, Zanobbio L, Selleri S, Ducio G.F, Mauro V, et al. Sodium-dependent glucose transporter-1 as a novel immunological player in the intestinal mucosa. J Immunol. 2008; 181:3126–3136. doi: 10.4049/jimmunol.181.5.3126. 3. Phai J.E, Hussain H.B, Moley J.F. Strategy for identification of novel glucose transporter family members by using internet-based genomic databases. Surgery. 2000; 128:946–519. doi: 10.1067/msy.2000.109967. 4. Sabino-Silva R, Freitas H.S, Lamers M.L, Okamoto M.M, Santos M.F, Machado U.F. Na+-glucose cotransporter SGLT1 protein in salivary glands: potential involvement in the diabetes-induced decrease in salivary flow. J Membr Biol. 2009; 228:63–69. doi: 10.1007/s00232-009-9159-3. 5. Sasaki T, Minoshima S, Shiohama A, Shintani A, Shimizu A, Asakawa S, et al. Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. Biochem Biophys Res Commun. 2001; 289:1218–1224. doi: 10.1006/bbrc.2001.6101.