INFLUENCE OF CHRONIC INTOXICATION WITH THE ORGANOPHOSPHORUS PESTICIDE ANTIO ON THE ACTIVITY OF RAT LYMPHOCYTE ACETYLCHOLINESTERASE
28.04.2023
International Scientific Journal "Science and Innovation". Series D. Volume 2 Issue 4
Khaydarova Dilorom Safoevna
Abstract. Chronic poisoning of rats with the organophosphate pesticide antio at doses of 3.5 mg/kg/day and 17.5 mg/kg/day (1/100 and 1/20 LD50, respectively) in the experiment revealed the presence of acetylcholinesterase activity in their lymphocytes. The results of the experiment showed that the activity of acetylcholinesterase is not the same in different subpopulations of lymphoid cells. The revealed dose-dependent inhibition of acetylcholinesterase in rat lymphocytes during chronic administration of the organophosphorus pesticide antio suggests that there may be a previously unknown mechanism of the immunosuppressive effect of organophosphorus compounds, implemented through the interference of these drugs in the processes of neurotransmitter regulation of the functions of lymphoid cells
Keywords: organophosphate pesticides, chronic poisoning, rat lymphocytes, acetylcholinesterase activity, acetylcholinesterase inhibition
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