27.04.2023 International Scientific Journal "Science and Innovation". Series D. Volume 2 Issue 4
Abstract. This review is devoted to the description of genetic changes, pathogenetic mechanisms and pathophysiology of hypertrophic cardiomyopathy based on the analysis of the latest published data. The current data on the role of identified numerous mutations of structural, structural and regulatory sarcomere proteins in the pathogenesis of cardiomyopathy are presented. The main hypotheses of the pathogenetic process are highlighted, special attention is paid to the violation of the regulation of calcium metabolism. The importance of genetic testing in patients with hypertrophic cardiomyopathy and their relatives is emphasized
Keywords: troponin T, troponin I.
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