SCIENCE & INNOVATION

MOLECULAR ASPECTS OF ENDOMETRIAL HYPERPLASIA

11.01.2023 International Scientific Journal "Science and Innovation". Series D. Volume 2 Issue 1

Abdulatipova Feruza Alisherovna

Abstract. The frequency of occurrence of hyperplastic processes of the endometrium, the lack of effectiveness of therapy from hormone therapy, as well as the likelihood of their malignancy puts hyperplastic processes of the endometrium among the most urgent problems of modern medicine. They are one of the very common causes of uterine bleeding and hospitalization of women in the hospital. A significant role in the formation of endometrial hyperplastic processes, along with hormonal disorders, is assigned to other activators of proliferative activity - growth factors, markers of proliferation and apoptosis, components of the extracellular matrix. Endometrial hyperplasia is a precancerous condition in which uneven thickening of the uterine mucosa occurs. This can cause uncomfortable symptoms in women, including heavy periods, postmenopausal bleeding, and anemia due to excess bleeding. Endometrial cancer is the most common gynecological malignancy in developed countries and its incidence is increasing. The study of the molecular aspects of endometrial hyperplasia improves the results of treatment and prevention of carcinomas.

Keywords: cell hyperplasia, endometrial carcinoma, molecular pathology, microsatellites, PTEN, k-RAS, beta-catenin, methylation.