1. World Health Organization (2015) Global health observatory data, risk concerns. 2. Arbeeny C.M. Addressing the unmet medical need for safe and effective weight loss therapies. Obes. Res. 2004, 12, 1191–1196. [Crossref], [Google Scholar] 3. Harrold J., Williams G., Wong S. Neuroendocrine targets for the treatment of obesity: physiological roles and unrealized opportunities. Curr Med Chem 2003, 3, 141–155. [Crossref], [Google Scholar] 4. Lowe M.E. Pancreatic triglyceride lipase and colipase: insights into dietary fat digestion. Gastroenterology. 1994;107:1524–36. 5. Elangham C.S. Current strategies in the development of anti-obesity drugs and their safety concerns. Vet.Pathol. 46:10-24, 2009 6. Colon-Gonzalez F., Kim G.W., Lin J.E., Valentino M.A., Waldman S.A. Obesity pharmacotherapy: what is next? Mol Asp Med. 2013;34:71–83. 1. 7.Orlistat (marketed as Alli and Xenical) Information. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm180076.htm 7. Weibel E.K., Hadvary P., Hochuli E., Kupfer E., Lengsfeld H. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. J Antibiot. 1987;40:1081–5. 8. Drent M.L., van der Veen, E.A. Lipase inhibition: a novel concept in the treatment of obesity. Int. J. Obes. Relat. Metab. Disord. 1993, 17, 241–244. [Google Scholar] 9. Dias D.A., Urban S., Roessner U. A historical overview of natural products in drug discovery. Meta. 2012;2:303–36. 10. Gupta M., Saxena S., Goyal D. Potential pancreatic lipase inhibitory activity of an endophytic Penicillium species. J Enzyme Inhib Med Chem. 2015;30:15–21 11. Gupta M., Saxena S., Goyal D. Lipase inhibitory activity of an endophytic fungal species of Aegle marmelos: a bioresource for potential pancreatic lipase inhibitors. Symbiosis. 2014; 64:149–57. 12. M.Katoch, A.Paul, G.Singh and S.N.C. Sridhar. Fungal endophytes associated with Viola odorata Linn. as bioresource for pancreatic lipase inhibitors. BMC Complementary and Alternative Medicine (2017) 17:385 13. Gulyamova T.G., Ruzieva D.M., Yoldosheva M.M., Rasulova G.A., Kondrasheva K.V. Screening of Pancreatic Lipase Inhibitors of Endophytic Fungi of Medicinal Plants in Uzbekistan. Biosci Biotech Res Asia 2022, Vol. 19(4), p. 1037-1044 14. Susheel Kumar, Nutan Kaushik. Endophytic Fungi Isolated from Oil-Seed Crop Jatropha curcas Produces Oil and Exhibit Antifungal Activity. 2013; Vol 8 (2 ) e56202 doi:10.1371/journal.pone.0056202 15. Katoch, A.Paul, G. Singh and S.N.C.Sridhar. Fungal endophytes associated with Viola odorata Linn. as bioresource for pancreatic lipase inhibitors Katoch et al. BMC Complementary and Alternative Medicine (2017) 17:385 DOI 10.1186/s12906-017-1893-y. 16. Visweswari G., Christopher R., Rajendra W. Phytochemical screening of active metabolites present in Withania Somnifera root: Role in traditional medicine. International Journal of Pharmaceutical Science and Research. 2013;4(7):2770-2776. 17. Kumar S., Kaushik N. (2013) Endophytic Fungi Isolated from Oil-Seed Crop Jatropha curcas Produces Oil and Exhibit Antifungal Activity. PLoS ONE 8(2): e56202. doi:10.1371/journal.pone.0056202 18. R.Ushasri and R.Anusha. In vitro anti-diabetic activity of ethanolic and acetone extracts of endophytic fungi Syncephalastrum racemosum isolated from the seaweed Gracilaria corticata by alpha-amylase inhibition assay method. Int.J.Curr.Microbiol.App.Sci (2015) 4(1): 254-259. 19. S.J.Higginbotham*, A.E.Arnold, A.Ibanez, C. Spadafora, P.D. Coley, T.A.Kursar. Bioactivity of Fungal Endophytes as a Function of Endophyte Taxonomy and the Taxonomy and Distribut ion of Their Host Plants.PLOS one, September 2013, V. 8, 9,1-119. 20. Min Qiu, Rui-sheng Xie, Yu Shi, Haihua Zhang &Hai-min Chen. Isolation and identification of two flavonoid-producing endophytic fungi from Ginkgo biloba L.Annals of Microbiology volume 60, pages143–150 (2010).