Starting from January 1, 2021, the Republic of Uzbekistan is switching to international financial reporting standards. When implementing IFRS, many problems arise related to personnel, regulatory legal acts and others. When switching to IFRS, special attention should be paid to IFRS 1 "First Application of International Financial Reporting Standards".
01.02.2023 Volume 2 Issue 2 View more Download
The article provides information about the formation of ecological culture of students of higher educational institutions and that students should have a basic scientific system of knowledge about the ways of human impact on the biosphere, environmental protection skills.
30.01.2023 Volume 2 Issue 2 View more Download
Currently, Nohodzkin's lymphoma is one of the most common oncohematological diseases in the world. Non-Hodgkin's lymphoma accounts for almost half of all cases of malignant lymphoproliferative lesions. A recent study of the history of this neoplasm has reported a steady increase in the incidence of non-Hodgkin's lymphoma [1,4,42].
29.01.2023 Volume 2 Issue 1 View more Download
Despite the development and implementation of modern effective methods of treatment and medicines, the economic burden of uncontrolled bronchial asthma on society is high. Uncontrolled bronchial asthma is associated with a decrease in the quality of life and the need for patients to contact the healthcare system.
29.01.2023 Volume 2 Issue 1 View more Download
The annual increase in patients with type 2 diabetes averages 12.3%. The largest number of patients with type 2 diabetes is patiants aged 51 to 58 years - 10.2% of men and 16.2% of women. Treatment of type 2 diabetes is aimed at minimizing the risk of developing micro- and macrovascular complications. The emergence of new antidiabetic drugs, the action of which is based on the enhancement of the effect of endogenous incretins, opens up new prospects in the treatment of type 2 diabetes. Despite the fact that 2 classes of these drugs (DPP-4 inhibitors and GLP analogs) belong to chemically different and structurally independent compounds, they have a similar mechanism of action, which consists in regulating glucose homeostasis by affecting the processes of glucose-dependent synthesis of insulin and glucagon, influencing consumption food and the promotion of chyme, on the proliferation, differentiation of pancreatic B-cells. A significant advantage of DPP-4 inhibitors is the possibility of their use in tablet form, unlike injectable GLP analogues. It is also important that DPP-4 inhibitors do not cause significant side effects, do not increase the incidence of hypoglycemia, and do not lead to weight gain. It has been shown that long-term subcutaneous administration of GLP-1 to patients with type 2 diabetes (for 6 weeks) improved the function of b-cells, reduced the level of glucose and glycosylated hemoglobin (HbA1c), and increased peripheral insulin sensitivity; in addition, a decrease in body weight of patients has been recorded. However, as already noted, the period of circulation of endogenous or exogenous GLP-1 in the blood is extremely short due to the rapid inactivation of incretins under the action of the dipeptidyl peptidase-4 enzyme. To ensure the practical use of native GLP-1 as a new agent in the treatment of type 2 DM, it is advisable to prevent the rapid breakdown of GLP-1 using DPP-4 inhibitors. Sodium-glucose cotransporter type 2 (SGLT2) inhibitors are a new class of oral antidiabetic drugs that reduce glycemia independently of insulin and beta-cell function. SGLT2 inhibitors, due to the unique mechanism of action that does not depend on the severity of insulin resistance and beta-cell deficiency, are equally effective both in patients with type 2 diabetes with a disease duration of less than one year and in patients with type 2 diabetes of a long course (more than ten years). All inhibitors are highly selective for SGLT2 over SGLT1. The safety of these drugs is due to an extremely narrow spectrum of action - inhibition of a specific protein, which is present almost exclusively in the epithelial cells of the proximal tubules of the nephron.
29.01.2023 Volume 2 Issue 1 View more Download
Various organic acids are obtained from cotton leaves. Stems and pods are a source of furfural, which is widely used in the production of synthetic resins and plastics. Much work has been done in this area on the interpretation of photosynthesis, respiration, metabolism and movement of substances, nutrition through roots and leaves and other processes
29.01.2023 Volume 2 Issue 1 View more Download
The article under discussion depicts the linguistic and conceptual picture of the world. The problem of studying the linguistic picture of the world is closely connected with the problem of the conceptual picture of the world which reflects the specificity of man and his being, his relationship with the world, the conditions of his existence. The author of the article considers that the linguistic picture of the world of a person reflects the general picture of the world.
29.01.2023 Volume 2 Issue 1 View more Download
This article highlights the field of robotics, which is developing today, and the role and importance of this field in the field of primary education. In particular, robotics and its substitutes in the formation of design competences of elementary school students are discussed separately. The article mentions that the field of robotics is the most effective direction in the formation of design competencies
29.01.2023 Volume 2 Issue 1 View more Download
SCIENCE & INNOVATION