Infertility is a pervasive concern affecting couples worldwide, with profound emotional, psychological, and social consequences. The advent of modern medical technologies has significantly advanced the diagnosis and treatment of infertility, providing new hope for individuals and couples struggling to conceive. This article critically analyzes the contemporary methods utilized in the diagnosis and treatment of infertility, evaluating their efficacy, ethical implications, and potential for personalized care. By examining a range of diagnostic techniques such as genetic testing, advanced imaging modalities, and hormonal profiling, as well as therapeutic interventions like assisted reproductive technologies (ART), pharmacological interventions, and lifestyle modifications, this article sheds light on the diverse tools available to clinicians and patients. The integration of these methods into clinical practice is explored, highlighting the need for a multidisciplinary approach that considers medical, ethical, psychological, and cultural aspects. Through this comprehensive analysis, the article aims to contribute to a better understanding of the current landscape of infertility management and inspire further research in this critical field
10.08.2023 Volume 2 Issue 8 View more Download
Congenital heart defects (CHDs) constitute a significant health challenge worldwide, affecting a substantial number of newborns and children. This article explores the current landscape of research and strategies focused on the prevention of congenital heart defects in children. The multifactorial nature of CHDs necessitates a comprehensive approach that encompasses genetic, environmental, and maternal health factors. By examining the latest advancements in prenatal screening, genetic counseling, nutritional interventions, and maternal lifestyle modifications, this article sheds light on promising avenues for reducing the incidence and impact of CHDs. Through a review of epidemiological data, molecular insights, and clinical interventions, this article underscores the importance of collaborative efforts between medical professionals, researchers, policymakers, and the public in striving for a future where the burden of congenital heart defects is minimized.
10.08.2023 Volume 2 Issue 8 View more Download
Objective: to assess the morphological abnormalities of red blood cells (RBC) in patients with COVID-19 and cardiovascular system (CVS) pathology. Material and methods. The study included 142 patients who were divided into 3 groups according to the following principle: combination of COVID-19 and CVS pathology (group 1, n=56); COVID-19 without CVS pathology (group 2, n=44); patients with CVS pathology without COVID-19 (group 3, n=42). Peripheral blood erythrocytes were studied. Morphological studies were carried out in the laboratories of pathological anatomy of the State Institution “RSSPMC for surgery named after V.Vakhidov" and RSH Zangiota-1. Results. Morphological features of peripheral blood erythrocytes in COVID-19-associated cardiovascular syndrome were revealed, characterized by an increase in the frequency of elevated erythrocyte distribution width (RDW) from 45.5% to 67.9% (p<0.05), and the average RDW from 13.1% (11, 8-15.4%) to 14.3% (12.6-15.8%) (p<0.0001); an increase in the proportion of abnormal forms from 13.6% in the isolated course of COVID-19 to 32.1% in the combination of COVID-19 with cardiovascular pathology (p<0.05), mainly due to ridged erythrocytes from 6.4+0.5% to 8.2+0.6% (p<0.001) and the proportion of irreversible forms of erythrocytes from 1.6+0.1% to 3.1+0.3% (p<0.001) increasing the risk of transferring the patient to the ICU (RR=6.0) and death (RR=4.33). Patients with more than 20% RBC abnormality had a statistically significant higher ICU admission rate (50.0%, 9 of 18; RR=6.0) than patients with less than 10% RBC abnormality (8.33%, 1 of 12, p=0.049), and patients with 10-20% abnormal RBCs (7.7%, 2 of 26, p=0.005). Conclusion. Patients with COVID-19-associated cardiovascular syndrome have a significant morphological heterogeneity in the shape and size of erythrocytes and their relationship with the progression and outcome of the disease.
06.08.2023 Volume 2 Issue 8 View more Download
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